Integrating Bifunctional Catalysis into Senior Undergraduate Organic Chemistry: A Laboratory Experiment on the Asymmetric Michael Addition Reaction
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| Title: | Integrating Bifunctional Catalysis into Senior Undergraduate Organic Chemistry: A Laboratory Experiment on the Asymmetric Michael Addition Reaction |
|---|---|
| Language: | English |
| Authors: | Lei Li, Fu Pi, Gu Zhan (ORCID |
| Source: | Journal of Chemical Education. 2024 101(8):3480-3484. |
| Availability: | Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc |
| Peer Reviewed: | Y |
| Page Count: | 5 |
| Publication Date: | 2024 |
| Document Type: | Journal Articles Reports - Research |
| Education Level: | Higher Education Postsecondary Education |
| Descriptors: | Undergraduate Students, College Science, Organic Chemistry, Laboratory Experiments, Spectroscopy, Laboratory Training, Science Process Skills |
| DOI: | 10.1021/acs.jchemed.4c00510 |
| ISSN: | 0021-9584 1938-1328 |
| Abstract: | An organic chemistry experiment designed for senior undergraduates focuses on bifunctional catalysis, a critical yet often omitted topic at the undergraduate level, but essential for advanced studies in chemistry. By utilization of a tertiary amine-thiourea catalyst in the asymmetric Michael addition reaction, the experiment showcases the superiority of bifunctional catalysis over traditional monofunctional approaches. Comprehensive training in designing control experiments, performing flash chromatography, and analyzing results with NMR and HPLC techniques equip students with modern synthetic skill sets. This experiment features easy operation and a relatively short time (4.5h, including 2-2.5 h reaction time). More importantly, it bridges the educational gap in understanding advanced catalytic mechanisms and techniques in organic chemistry. |
| Abstractor: | As Provided |
| Entry Date: | 2024 |
| Accession Number: | EJ1437997 |
| Database: | ERIC |
| Abstract: | An organic chemistry experiment designed for senior undergraduates focuses on bifunctional catalysis, a critical yet often omitted topic at the undergraduate level, but essential for advanced studies in chemistry. By utilization of a tertiary amine-thiourea catalyst in the asymmetric Michael addition reaction, the experiment showcases the superiority of bifunctional catalysis over traditional monofunctional approaches. Comprehensive training in designing control experiments, performing flash chromatography, and analyzing results with NMR and HPLC techniques equip students with modern synthetic skill sets. This experiment features easy operation and a relatively short time (4.5h, including 2-2.5 h reaction time). More importantly, it bridges the educational gap in understanding advanced catalytic mechanisms and techniques in organic chemistry. |
|---|---|
| ISSN: | 0021-9584 1938-1328 |
| DOI: | 10.1021/acs.jchemed.4c00510 |
