The Association between Repeated Measured Febrile Episodes during Early Childhood and Attention Deficit Hyperactivity Disorder: A Large-Scale Population-Based Study
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| Title: | The Association between Repeated Measured Febrile Episodes during Early Childhood and Attention Deficit Hyperactivity Disorder: A Large-Scale Population-Based Study |
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| Language: | English |
| Authors: | Ariel Israel, Eugene Merzon (ORCID |
| Source: | Journal of Attention Disorders. 2024 28(5):677-685. |
| Availability: | SAGE Publications. 2455 Teller Road, Thousand Oaks, CA 91320. Tel: 800-818-7243; Tel: 805-499-9774; Fax: 800-583-2665; e-mail: journals@sagepub.com; Web site: https://sagepub.com |
| Peer Reviewed: | Y |
| Page Count: | 9 |
| Publication Date: | 2024 |
| Document Type: | Journal Articles Reports - Research |
| Descriptors: | Physiology, Young Children, Incidence, Attention Deficit Hyperactivity Disorder, Correlation, Children, Adolescents, Probability, Neurology, Foreign Countries |
| Geographic Terms: | Israel |
| DOI: | 10.1177/10870547231215289 |
| ISSN: | 1087-0547 1557-1246 |
| Abstract: | Objective: We examined the association between the number, magnitude, and frequency of febrile episodes during the 0 to 4 years of life and subsequent diagnosis of ADHD. Methods: This population-based case-control study in an Israeli HMO, Leumit Health Services (LHS), uses a database for all LHS members aged 5 to 18 years between 1/1/2002 and 1/30/2022. The number and magnitude of measured fever episodes during the 0 to 4 years were recorded in individuals with ADHD (N = 18,558) and individually matched non-ADHD controls in a 1:2 ratio (N = 37,116). Results: A significant, independent association was found between the number and magnitude of febrile episodes during the 0 to 4 years and the probability of a later diagnosis of ADHD. Children who never had a measured temperature >37.5°C had a significantly lower rate of ADHD (OR = 0.834, 95% CI [0.802, 0.866], p < 0.0001). Conclusions: Febrile episodes during 0 to 4 years are associated with a significantly increased rate of a later diagnosis of ADHD in a dose-response relationship. |
| Abstractor: | As Provided |
| Entry Date: | 2024 |
| Accession Number: | EJ1440635 |
| Database: | ERIC |
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| Abstract: | Objective: We examined the association between the number, magnitude, and frequency of febrile episodes during the 0 to 4 years of life and subsequent diagnosis of ADHD. Methods: This population-based case-control study in an Israeli HMO, Leumit Health Services (LHS), uses a database for all LHS members aged 5 to 18 years between 1/1/2002 and 1/30/2022. The number and magnitude of measured fever episodes during the 0 to 4 years were recorded in individuals with ADHD (N = 18,558) and individually matched non-ADHD controls in a 1:2 ratio (N = 37,116). Results: A significant, independent association was found between the number and magnitude of febrile episodes during the 0 to 4 years and the probability of a later diagnosis of ADHD. Children who never had a measured temperature >37.5°C had a significantly lower rate of ADHD (OR = 0.834, 95% CI [0.802, 0.866], p < 0.0001). Conclusions: Febrile episodes during 0 to 4 years are associated with a significantly increased rate of a later diagnosis of ADHD in a dose-response relationship. |
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| ISSN: | 1087-0547 1557-1246 |
| DOI: | 10.1177/10870547231215289 |
