Aberrant Neurofunctional Responses during Emotional and Attentional Processing Differentiate ADHD Youth with and without a Family History of Bipolar I Disorder
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| Title: | Aberrant Neurofunctional Responses during Emotional and Attentional Processing Differentiate ADHD Youth with and without a Family History of Bipolar I Disorder |
|---|---|
| Language: | English |
| Authors: | L. Rodrigo Patino, Allison S. Wilson, Maxwell J. Tallman, Thomas J. Blom, Melissa P. DelBello, Robert K. McNamara (ORCID |
| Source: | Journal of Attention Disorders. 2024 28(5):820-833. |
| Availability: | SAGE Publications. 2455 Teller Road, Thousand Oaks, CA 91320. Tel: 800-818-7243; Tel: 805-499-9774; Fax: 800-583-2665; e-mail: journals@sagepub.com; Web site: https://sagepub.com |
| Peer Reviewed: | Y |
| Page Count: | 14 |
| Publication Date: | 2024 |
| Sponsoring Agency: | National Institute of Mental Health (NIMH) (DHHS/NIH) |
| Contract Number: | R01097818 |
| Document Type: | Journal Articles Reports - Research |
| Descriptors: | Attention Deficit Hyperactivity Disorder, Emotional Response, Attention, Cognitive Processes, Mental Disorders, Brain Hemisphere Functions, Responses, Neurological Organization, Heredity, Children, Adolescents |
| Assessment and Survey Identifiers: | Child Behavior Checklist |
| DOI: | 10.1177/10870547231215292 |
| ISSN: | 1087-0547 1557-1246 |
| Abstract: | Objective: To compare neurofunctional responses in emotional and attentional networks of psychostimulant-free ADHD youth with and without familial risk for bipolar I disorder (BD). Methods: ADHD youth with (high-risk, HR, n = 48) and without (low-risk, LR, n = 50) a first-degree relative with BD and healthy controls (n = 46) underwent functional magnetic resonance imaging while performing a continuous performance task with emotional distracters. Region-of-interest analyses were performed for bilateral amygdala (AMY), ventrolateral (VLPFC) and dorsolateral (DLPFC) prefrontal cortex, and anterior (ACC) and posterior cingulate cortex (PCC). Results: Compared with HC, HR, but not LR, exhibited predominantly left-lateralized AMY, VLPFC, DLPFC, PCC, and rostral ACC hyperactivation to emotional distractors, whereas LR exhibited right VLPFC and bilateral dorsal ACC hypoactivation to attentional targets. Regional responses correlated with emotional and attention symptoms. Conclusion: Aberrant neurofunctional responses during emotional and attentional processing differentiate ADHD youth with and without a family history of BD and correlate with relevant symptoms ratings. |
| Abstractor: | As Provided |
| Entry Date: | 2024 |
| Accession Number: | EJ1440637 |
| Database: | ERIC |
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| Abstract: | Objective: To compare neurofunctional responses in emotional and attentional networks of psychostimulant-free ADHD youth with and without familial risk for bipolar I disorder (BD). Methods: ADHD youth with (high-risk, HR, n = 48) and without (low-risk, LR, n = 50) a first-degree relative with BD and healthy controls (n = 46) underwent functional magnetic resonance imaging while performing a continuous performance task with emotional distracters. Region-of-interest analyses were performed for bilateral amygdala (AMY), ventrolateral (VLPFC) and dorsolateral (DLPFC) prefrontal cortex, and anterior (ACC) and posterior cingulate cortex (PCC). Results: Compared with HC, HR, but not LR, exhibited predominantly left-lateralized AMY, VLPFC, DLPFC, PCC, and rostral ACC hyperactivation to emotional distractors, whereas LR exhibited right VLPFC and bilateral dorsal ACC hypoactivation to attentional targets. Regional responses correlated with emotional and attention symptoms. Conclusion: Aberrant neurofunctional responses during emotional and attentional processing differentiate ADHD youth with and without a family history of BD and correlate with relevant symptoms ratings. |
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| ISSN: | 1087-0547 1557-1246 |
| DOI: | 10.1177/10870547231215292 |
