A Multidisciplinary Team-Based Classroom Exercise for Small Molecule Drug Discovery
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| Title: | A Multidisciplinary Team-Based Classroom Exercise for Small Molecule Drug Discovery |
|---|---|
| Language: | English |
| Authors: | Charlotte A. Dodson (ORCID |
| Source: | Journal of Chemical Education. 2023 100(9):3320-3332. |
| Availability: | Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc |
| Peer Reviewed: | Y |
| Page Count: | 13 |
| Publication Date: | 2023 |
| Document Type: | Journal Articles Reports - Descriptive |
| Education Level: | Higher Education Postsecondary Education |
| Descriptors: | Drug Therapy, Pharmacy, Teamwork, Interdisciplinary Approach, Graduate Students, Workshops, Scientific Research, Molecular Structure, Decision Making, Data Analysis, Industry, Undergraduate Students, Organic Chemistry, Biochemistry, Problem Solving, Computer Software, Teaching Methods, Computer Simulation |
| ISSN: | 0021-9584 1938-1328 |
| Abstract: | Industrial drug discovery teams encompass scientists from multiple specialties and require participants to communicate effectively across disciplinary boundaries. In this paper, we present an undergraduate or graduate classroom simulation of this environment. Over a series of five workshops, student teams of mixed scientific backgrounds perform five iterations of the chemistry cycle of small molecule drug discovery. Students analyze physicochemical, structural, and (fictional) assay data and use these to design new compounds for testing. Simulated assay results are returned to students who use the information in the design of subsequent compounds. After workshop 5, each team selects a single lead compound, supported by a potential synthetic route, a portfolio of assay data, and logical scientific decision-making. Our exercise provides students with opportunities for hands-on student-responsive data handing, team-building, and technical knowledge acquisition--all within an industrially relevant scientific scenario. |
| Abstractor: | As Provided |
| Entry Date: | 2024 |
| Accession Number: | EJ1444492 |
| Database: | ERIC |
| Abstract: | Industrial drug discovery teams encompass scientists from multiple specialties and require participants to communicate effectively across disciplinary boundaries. In this paper, we present an undergraduate or graduate classroom simulation of this environment. Over a series of five workshops, student teams of mixed scientific backgrounds perform five iterations of the chemistry cycle of small molecule drug discovery. Students analyze physicochemical, structural, and (fictional) assay data and use these to design new compounds for testing. Simulated assay results are returned to students who use the information in the design of subsequent compounds. After workshop 5, each team selects a single lead compound, supported by a potential synthetic route, a portfolio of assay data, and logical scientific decision-making. Our exercise provides students with opportunities for hands-on student-responsive data handing, team-building, and technical knowledge acquisition--all within an industrially relevant scientific scenario. |
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| ISSN: | 0021-9584 1938-1328 |
