Consanguinity as a Risk Factor for Autism
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| Title: | Consanguinity as a Risk Factor for Autism |
|---|---|
| Language: | English |
| Authors: | Fouad A. Alshaban, Mohammad Aldosari, Iman Ghazal, Hawraa Al-Shammari, Saba ElHag, I. Richard Thompson, Jennifer Bruder, Hibah Shaath, Fatema Al-Faraj, Mohamed Tolefat, Assal Nasir, Eric Fombonne (ORCID |
| Source: | Journal of Autism and Developmental Disorders. 2025 55(6):1945-1952. |
| Availability: | Springer. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: customerservice@springernature.com; Web site: https://link.springer.com/ |
| Peer Reviewed: | Y |
| Page Count: | 8 |
| Publication Date: | 2025 |
| Document Type: | Journal Articles Reports - Research |
| Descriptors: | Risk, Symptoms (Individual Disorders), Autism Spectrum Disorders, Environmental Influences, Genetic Disorders, Genetics, Family Influence, Children, Foreign Countries, Family Relationship |
| Geographic Terms: | Qatar |
| DOI: | 10.1007/s10803-023-06137-w |
| ISSN: | 0162-3257 1573-3432 |
| Abstract: | Purpose: Genetic and environmental risk factors associated with Autism Spectrum Disorders (ASD) continue to be a focus of research worldwide. Consanguinity, the cultural practice of marrying within a family, is common in cultures and societies of the Middle East, North Africa and parts of Asia. Consanguinity has been investigated as a risk factor for ASD in a limited number of studies, with mixed results. We employed registry and survey data from Qatar to evaluate the role of consanguinity as a risk factor for ASD. Methods: Data were sourced from a national registry and a population-based survey of autism recently conducted in Qatar. We selected a sample of 891 children (mean age: 8.3 years) with (N = 361) or without (N = 530) ASD. Data on consanguinity and covariates were collected through questionnaires and interviews. Results: The prevalence of consanguinity in the overall sample was 41.2% with no significant difference between cases and controls (42.1% vs 41.3%; p = 0.836). In adjusted multiple logistic regression analyses, consanguinity was not associated with risk of ASD (aOR = 1.065; 95% CI: 0.751-1.509; NS). Conclusion: Parental consanguinity was not associated with autism risk in our study. Replication in other populations with high rates of consanguineous unions is recommended. |
| Abstractor: | As Provided |
| Entry Date: | 2025 |
| Accession Number: | EJ1470948 |
| Database: | ERIC |
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| Abstract: | Purpose: Genetic and environmental risk factors associated with Autism Spectrum Disorders (ASD) continue to be a focus of research worldwide. Consanguinity, the cultural practice of marrying within a family, is common in cultures and societies of the Middle East, North Africa and parts of Asia. Consanguinity has been investigated as a risk factor for ASD in a limited number of studies, with mixed results. We employed registry and survey data from Qatar to evaluate the role of consanguinity as a risk factor for ASD. Methods: Data were sourced from a national registry and a population-based survey of autism recently conducted in Qatar. We selected a sample of 891 children (mean age: 8.3 years) with (N = 361) or without (N = 530) ASD. Data on consanguinity and covariates were collected through questionnaires and interviews. Results: The prevalence of consanguinity in the overall sample was 41.2% with no significant difference between cases and controls (42.1% vs 41.3%; p = 0.836). In adjusted multiple logistic regression analyses, consanguinity was not associated with risk of ASD (aOR = 1.065; 95% CI: 0.751-1.509; NS). Conclusion: Parental consanguinity was not associated with autism risk in our study. Replication in other populations with high rates of consanguineous unions is recommended. |
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| ISSN: | 0162-3257 1573-3432 |
| DOI: | 10.1007/s10803-023-06137-w |
