The Effects of 'Crocus sativus' (Saffron) on ADHD: A Systematic Review
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| Title: | The Effects of 'Crocus sativus' (Saffron) on ADHD: A Systematic Review |
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| Language: | English |
| Authors: | Sepideh Seyedi-Sahebari, Sara Farhang, Mostafa Araj-Khodaei, Shahin Akhondzadeh, Amirreza Naseri (ORCID |
| Source: | Journal of Attention Disorders. 2024 28(1):14-24. |
| Availability: | SAGE Publications. 2455 Teller Road, Thousand Oaks, CA 91320. Tel: 800-818-7243; Tel: 805-499-9774; Fax: 800-583-2665; e-mail: journals@sagepub.com; Web site: https://sagepub.com |
| Peer Reviewed: | Y |
| Page Count: | 11 |
| Publication Date: | 2024 |
| Document Type: | Journal Articles Information Analyses |
| Descriptors: | Attention Deficit Hyperactivity Disorder, Therapy, Plants (Botany), Outcomes of Treatment, Safety, Patients |
| DOI: | 10.1177/10870547231203176 |
| ISSN: | 1087-0547 1557-1246 |
| Abstract: | Background and Aim: "Crocus sativus" also known as saffron, is one of the most popular traditional plants. This study aims to evaluate the efficacy and safety of saffron extracts in ADHD. Method: This study includes clinical trial studies that assessed the efficacy and/or safety of saffron in ADHD patients. Non-English papers, review articles, commentaries, letters, observational studies, thesis, animal studies, in-vitro studies, and conference abstracts were not included. The risk of bias in randomized studies was evaluated based on the Cochrane RoB.2, and risk of bias in pre-post intervention studies was assessed using the ROBINS-I tool. Results: Four studies met our inclusion criteria with a total of 118 patients. The results manifested an efficient role of saffron as either an adjuvant therapy to MPH or a single therapy against ADHD, without significant safety issues. Discussion: Saffron demonstrates promise in improving ADHD symptoms, with an acceptable safety profile. Future well-designed multicentral studies are suggested. |
| Abstractor: | As Provided |
| Entry Date: | 2025 |
| Accession Number: | EJ1475484 |
| Database: | ERIC |
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| Abstract: | Background and Aim: "Crocus sativus" also known as saffron, is one of the most popular traditional plants. This study aims to evaluate the efficacy and safety of saffron extracts in ADHD. Method: This study includes clinical trial studies that assessed the efficacy and/or safety of saffron in ADHD patients. Non-English papers, review articles, commentaries, letters, observational studies, thesis, animal studies, in-vitro studies, and conference abstracts were not included. The risk of bias in randomized studies was evaluated based on the Cochrane RoB.2, and risk of bias in pre-post intervention studies was assessed using the ROBINS-I tool. Results: Four studies met our inclusion criteria with a total of 118 patients. The results manifested an efficient role of saffron as either an adjuvant therapy to MPH or a single therapy against ADHD, without significant safety issues. Discussion: Saffron demonstrates promise in improving ADHD symptoms, with an acceptable safety profile. Future well-designed multicentral studies are suggested. |
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| ISSN: | 1087-0547 1557-1246 |
| DOI: | 10.1177/10870547231203176 |
