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Utilidad del modelo MPB-INFURG-SEMES para predecir bacteriemia en el paciente con neoplasia sólida en el Servicio de Urgencias.

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Title: Utilidad del modelo MPB-INFURG-SEMES para predecir bacteriemia en el paciente con neoplasia sólida en el Servicio de Urgencias.
Alternate Title: Usefulness of the MPB-INFURG-SEMES model to predict bacteremia in the patient with solid tumor in the Emergency Department.
Authors: Muelas González, María1, Torner Marchesi, Elena1, Peláez Díaz, Gabriela1, Ramos Aranguez, Marta1, Cabañas Morafraile, Javier2, López Forero, William2, Rubio Díaz, Rafael2, González del Castillo, Juan3, Javier Candel, Francisco4, Julián-Jiménez, Agustín2,5 agustinj@sescam.jccm.es
Source: Revista Española de Quimioterapia. jun2024, Vol. 37 Issue 3, p257-265. 9p.
Abstract (English): Objective. To analyse a new risk score to predict bacteremia (MPB-INFURG-SEMES) in the patients with solid tumor attender for infection in the emergency departments (ED). Patients and methods. Prospective, multicenter observational cohort study of blood cultures (BC) obtained from adult patients with solid neoplasia treated in 63 EDs for infection from November 1, 2019, to March 31, 2020. The predictive ability of the model was analyzed with the area under the Receiver Operating Characteristic curve (AUC-ROC). The prognostic performance for true bacteremia was calculated with the chosen cut-off for getting the sensitivity, specificity, positive predictive value and negative predictive value. Results. A total of 857 blood samples wered cultured. True cases of bacteremia were confirmed in 196 (22.9%). The remaining 661 cultures (77.1%) wered negative. And, 42 (4.9%) were judged to be contaminated. The model's area under the receiver operating characteristic curve was 0.923 (95% CI, 0.896-0.950). The prognostic performance with a model's cutoff value of ≥ 5 points achieved 95.74% (95% CI, 94,92-96.56) sensitivity, 76.06% (95% CI, 75.24-76.88) specificity, 53.42% (95% CI, 52.60-54.24) positive predictive value and 98.48% (95% CI, 97.66- 99.30) negative predictive value. Conclusion. The MPB-INFURG-SEMES score is useful for predicting bacteremia in the adults patients with solid tumor seen in the ED. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Objetivo. Analizar la utilidad de un nuevo modelo predictivo de bacteriemia (MPB-INFURG-SEMES) en pacientes con neoplasia sólida atendidos por infección en el servicio de urgencias (SU). Pacientes y métodos. Estudio observacional de cohortes prospectivo y multicéntrico de los hemocultivos (HC) obtenidos de pacientes adultos con neoplasia sólida atendidos en 63 SU por infección desde el 1 de noviembre de 2019 hasta el 31 de marzo de 2020. Se analizó la capacidad predictiva del modelo con el área bajo la curva (ABC) de la característica operativa del receptor (COR) y se calculó el rendimiento diagnóstico del punto de corte (PC) del modelo elegido con los cálculos de la sensibilidad, la especificidad, el valor predictivo positivo y el valor predictivo negativo. Resultados. Se incluyeron 857 episodios de HC extraídos. De ellos, se consideraron como bacteriemias verdaderas 196 (22,9%) y como HC negativos 661 (77,1%). Entre los negativos, 42 (4,9%) se consideraron contaminados. El ABC-COR del modelo aplicado fue de 0,923 (IC 95%: 0,896-0,950). El rendimiento diagnóstico del modelo con un PC ≥ 5 puntos consigue una sensibilidad de 95,74% (IC 95%: 94,92-96,56), especificidad de 76,06% (IC 95%: 75,24-76,88) un valor predictivo positivo de 53,42% (IC 95%: 52,60-54,24) y un valor predictivo negativo de 98,48% (IC 95%: 97,66-99,30). Conclusión. El modelo MPB-INFURG-SEMES podría ser útil para predecir bacteriemia en los pacientes adultos con neoplasia sólida atendidos en el SU por un episodio de infección. [ABSTRACT FROM AUTHOR]
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Database: MedicLatina
Description
Abstract:Objective. To analyse a new risk score to predict bacteremia (MPB-INFURG-SEMES) in the patients with solid tumor attender for infection in the emergency departments (ED). Patients and methods. Prospective, multicenter observational cohort study of blood cultures (BC) obtained from adult patients with solid neoplasia treated in 63 EDs for infection from November 1, 2019, to March 31, 2020. The predictive ability of the model was analyzed with the area under the Receiver Operating Characteristic curve (AUC-ROC). The prognostic performance for true bacteremia was calculated with the chosen cut-off for getting the sensitivity, specificity, positive predictive value and negative predictive value. Results. A total of 857 blood samples wered cultured. True cases of bacteremia were confirmed in 196 (22.9%). The remaining 661 cultures (77.1%) wered negative. And, 42 (4.9%) were judged to be contaminated. The model's area under the receiver operating characteristic curve was 0.923 (95% CI, 0.896-0.950). The prognostic performance with a model's cutoff value of ≥ 5 points achieved 95.74% (95% CI, 94,92-96.56) sensitivity, 76.06% (95% CI, 75.24-76.88) specificity, 53.42% (95% CI, 52.60-54.24) positive predictive value and 98.48% (95% CI, 97.66- 99.30) negative predictive value. Conclusion. The MPB-INFURG-SEMES score is useful for predicting bacteremia in the adults patients with solid tumor seen in the ED. [ABSTRACT FROM AUTHOR]
ISSN:02143429
DOI:10.37201/req/004.2024