Enfermedad de Kawasaki resistente al tratamiento con inmunoglobulinas. Infliximab como nueva terapia.

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Bibliographic Details
Title:	Enfermedad de Kawasaki resistente al tratamiento con inmunoglobulinas. Infliximab como nueva terapia.
Alternate Title:	Infliximab as nobel therapy for refractory Kawasaki disease.
Authors:	Denia, M. Martos¹ mmartos.cp.ics@gencat.cat
Source:	Acta Pediátrica Española. jul-sep2011, Vol. 69 Issue 7/8, p361-364. 4p.
Subjects:	MUCOCUTANEOUS lymph node syndrome, COMMUNICABLE diseases in children, LYMPH node diseases, ANEURYSMS, VASCULAR diseases
Abstract (English):	Kawasaki disease (KD) is a multisystemic vasculitis of unknown etiology, with coronary artery aneurisms occurring in 25% of untreated cases with conventional treatment of intravenous immunoglobulin (IVIG) and acetylsalicylic acid (AAS) to high dose. We describe the case of a 5-year-old boy and 10 months with KD resistant to the conventional therapy. He received a total of 3 doses of IVIG and 3 pulses of methylprednisolone without success. He was treated with infliximab (anti tumor necrosis factor-α) with a good response. In spite of presenting signs of severe and persistent vasculitis, evidenced by ongoing fever and elevation of the reactants of acute phase, our patient didn't develop coronary aneurysms. [ABSTRACT FROM AUTHOR]
Abstract (Spanish):	La enfermedad de Kawasaki (EK) es una vasculitis multisistémica de etiología desconocida. Pueden afectarse las arterias coronarias hasta en el 25% de los casos que no reciben tratamiento precoz con inmunoglobulinas intravenosas (IGIV) y ácido acetilsalicílico en dosis elevadas. Se presenta el caso de un niño de 5 años y 10 meses de edad con EK resistente al tratamiento convencional. Recibió 3 dosis de IGIV y 3 dosis de metilprednisolona, sin resultados terapéuticos; finalmente respondió a infliximab (anticuerpo contra el factor de necrosis tumoral alfa). A pesar de presentar signos de vasculitis severa y persistente, manifestada por una fiebre que no cedía y una elevación de los reactantes de fase aguda, el paciente no presentó aneurismas coronarios. [ABSTRACT FROM AUTHOR]
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Database:	MedicLatina

Description
Abstract:	Kawasaki disease (KD) is a multisystemic vasculitis of unknown etiology, with coronary artery aneurisms occurring in 25% of untreated cases with conventional treatment of intravenous immunoglobulin (IVIG) and acetylsalicylic acid (AAS) to high dose. We describe the case of a 5-year-old boy and 10 months with KD resistant to the conventional therapy. He received a total of 3 doses of IVIG and 3 pulses of methylprednisolone without success. He was treated with infliximab (anti tumor necrosis factor-α) with a good response. In spite of presenting signs of severe and persistent vasculitis, evidenced by ongoing fever and elevation of the reactants of acute phase, our patient didn't develop coronary aneurysms. [ABSTRACT FROM AUTHOR]
ISSN:	00016640