Enfermedad de Kawasaki resistente al tratamiento con inmunoglobulinas. Infliximab como nueva terapia.
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| Title: | Enfermedad de Kawasaki resistente al tratamiento con inmunoglobulinas. Infliximab como nueva terapia. |
|---|---|
| Alternate Title: | Infliximab as nobel therapy for refractory Kawasaki disease. |
| Authors: | Denia, M. Martos1 mmartos.cp.ics@gencat.cat |
| Source: | Acta Pediátrica Española. jul-sep2011, Vol. 69 Issue 7/8, p361-364. 4p. |
| Subjects: | MUCOCUTANEOUS lymph node syndrome, COMMUNICABLE diseases in children, LYMPH node diseases, ANEURYSMS, VASCULAR diseases |
| Abstract (English): | Kawasaki disease (KD) is a multisystemic vasculitis of unknown etiology, with coronary artery aneurisms occurring in 25% of untreated cases with conventional treatment of intravenous immunoglobulin (IVIG) and acetylsalicylic acid (AAS) to high dose. We describe the case of a 5-year-old boy and 10 months with KD resistant to the conventional therapy. He received a total of 3 doses of IVIG and 3 pulses of methylprednisolone without success. He was treated with infliximab (anti tumor necrosis factor-α) with a good response. In spite of presenting signs of severe and persistent vasculitis, evidenced by ongoing fever and elevation of the reactants of acute phase, our patient didn't develop coronary aneurysms. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | La enfermedad de Kawasaki (EK) es una vasculitis multisistémica de etiología desconocida. Pueden afectarse las arterias coronarias hasta en el 25% de los casos que no reciben tratamiento precoz con inmunoglobulinas intravenosas (IGIV) y ácido acetilsalicílico en dosis elevadas. Se presenta el caso de un niño de 5 años y 10 meses de edad con EK resistente al tratamiento convencional. Recibió 3 dosis de IGIV y 3 dosis de metilprednisolona, sin resultados terapéuticos; finalmente respondió a infliximab (anticuerpo contra el factor de necrosis tumoral alfa). A pesar de presentar signos de vasculitis severa y persistente, manifestada por una fiebre que no cedía y una elevación de los reactantes de fase aguda, el paciente no presentó aneurismas coronarios. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Pediátrica Española is the property of Ediciones Mayo and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: lth DbLabel: MedicLatina An: 82296461 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Enfermedad de Kawasaki resistente al tratamiento con inmunoglobulinas. Infliximab como nueva terapia. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Infliximab as nobel therapy for refractory Kawasaki disease. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Denia%2C+M%2E+Martos%22">Denia, M. Martos</searchLink><relatesTo>1</relatesTo><i> mmartos.cp.ics@gencat.cat</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Pediátrica+Española%22">Acta Pediátrica Española</searchLink>. jul-sep2011, Vol. 69 Issue 7/8, p361-364. 4p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22MUCOCUTANEOUS+lymph+node+syndrome%22">MUCOCUTANEOUS lymph node syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22COMMUNICABLE+diseases+in+children%22">COMMUNICABLE diseases in children</searchLink><br /><searchLink fieldCode="DE" term="%22LYMPH+node+diseases%22">LYMPH node diseases</searchLink><br /><searchLink fieldCode="DE" term="%22ANEURYSMS%22">ANEURYSMS</searchLink><br /><searchLink fieldCode="DE" term="%22VASCULAR+diseases%22">VASCULAR diseases</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Kawasaki disease (KD) is a multisystemic vasculitis of unknown etiology, with coronary artery aneurisms occurring in 25% of untreated cases with conventional treatment of intravenous immunoglobulin (IVIG) and acetylsalicylic acid (AAS) to high dose. We describe the case of a 5-year-old boy and 10 months with KD resistant to the conventional therapy. He received a total of 3 doses of IVIG and 3 pulses of methylprednisolone without success. He was treated with infliximab (anti tumor necrosis factor-α) with a good response. In spite of presenting signs of severe and persistent vasculitis, evidenced by ongoing fever and elevation of the reactants of acute phase, our patient didn't develop coronary aneurysms. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: La enfermedad de Kawasaki (EK) es una vasculitis multisistémica de etiología desconocida. Pueden afectarse las arterias coronarias hasta en el 25% de los casos que no reciben tratamiento precoz con inmunoglobulinas intravenosas (IGIV) y ácido acetilsalicílico en dosis elevadas. Se presenta el caso de un niño de 5 años y 10 meses de edad con EK resistente al tratamiento convencional. Recibió 3 dosis de IGIV y 3 dosis de metilprednisolona, sin resultados terapéuticos; finalmente respondió a infliximab (anticuerpo contra el factor de necrosis tumoral alfa). A pesar de presentar signos de vasculitis severa y persistente, manifestada por una fiebre que no cedía y una elevación de los reactantes de fase aguda, el paciente no presentó aneurismas coronarios. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Pediátrica Española is the property of Ediciones Mayo and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 4 StartPage: 361 Subjects: – SubjectFull: MUCOCUTANEOUS lymph node syndrome Type: general – SubjectFull: COMMUNICABLE diseases in children Type: general – SubjectFull: LYMPH node diseases Type: general – SubjectFull: ANEURYSMS Type: general – SubjectFull: VASCULAR diseases Type: general Titles: – TitleFull: Enfermedad de Kawasaki resistente al tratamiento con inmunoglobulinas. Infliximab como nueva terapia. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Denia, M. Martos IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: jul-sep2011 Type: published Y: 2011 Identifiers: – Type: issn-print Value: 00016640 Numbering: – Type: volume Value: 69 – Type: issue Value: 7/8 Titles: – TitleFull: Acta Pediátrica Española Type: main |
| ResultId | 1 |
