Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R).
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| Title: | Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). |
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| Authors: | Pelletier JC; Department of Chemical Sciences, Musculoskeletal Biology, and Drug Safety and Metabolism, Wyeth Research, Collegeville, Pennsylvania 19426, USA., Chengalvala MV, Cottom JE, Feingold IB, Green DM, Hauze DB, Huselton CA, Jetter JW, Kopf GS, Lundquist JT, Magolda RL, Mann CW, Mehlmann JF, Rogers JF, Shanno LK, Adams WR, Tio CO, Wrobel JE |
| Source: | Journal of medicinal chemistry [J Med Chem] 2009 Apr 09; Vol. 52 (7), pp. 2148-52. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 19271735 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Pelletier+JC%22">Pelletier JC</searchLink>; Department of Chemical Sciences, Musculoskeletal Biology, and Drug Safety and Metabolism, Wyeth Research, Collegeville, Pennsylvania 19426, USA.<br /><searchLink fieldCode="AU" term="%22Chengalvala+MV%22">Chengalvala MV</searchLink><br /><searchLink fieldCode="AU" term="%22Cottom+JE%22">Cottom JE</searchLink><br /><searchLink fieldCode="AU" term="%22Feingold+IB%22">Feingold IB</searchLink><br /><searchLink fieldCode="AU" term="%22Green+DM%22">Green DM</searchLink><br /><searchLink fieldCode="AU" term="%22Hauze+DB%22">Hauze DB</searchLink><br /><searchLink fieldCode="AU" term="%22Huselton+CA%22">Huselton CA</searchLink><br /><searchLink fieldCode="AU" term="%22Jetter+JW%22">Jetter JW</searchLink><br /><searchLink fieldCode="AU" term="%22Kopf+GS%22">Kopf GS</searchLink><br /><searchLink fieldCode="AU" term="%22Lundquist+JT%22">Lundquist JT</searchLink><br /><searchLink fieldCode="AU" term="%22Magolda+RL%22">Magolda RL</searchLink><br /><searchLink fieldCode="AU" term="%22Mann+CW%22">Mann CW</searchLink><br /><searchLink fieldCode="AU" term="%22Mehlmann+JF%22">Mehlmann JF</searchLink><br /><searchLink fieldCode="AU" term="%22Rogers+JF%22">Rogers JF</searchLink><br /><searchLink fieldCode="AU" term="%22Shanno+LK%22">Shanno LK</searchLink><br /><searchLink fieldCode="AU" term="%22Adams+WR%22">Adams WR</searchLink><br /><searchLink fieldCode="AU" term="%22Tio+CO%22">Tio CO</searchLink><br /><searchLink fieldCode="AU" term="%22Wrobel+JE%22">Wrobel JE</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2009 Apr 09; Vol. 52 (7), pp. 2148-52. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=19271735 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/jm801572m Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 2148 Titles: – TitleFull: Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Pelletier JC – PersonEntity: Name: NameFull: Chengalvala MV – PersonEntity: Name: NameFull: Cottom JE – PersonEntity: Name: NameFull: Feingold IB – PersonEntity: Name: NameFull: Green DM – PersonEntity: Name: NameFull: Hauze DB – PersonEntity: Name: NameFull: Huselton CA – PersonEntity: Name: NameFull: Jetter JW – PersonEntity: Name: NameFull: Kopf GS – PersonEntity: Name: NameFull: Lundquist JT – PersonEntity: Name: NameFull: Magolda RL – PersonEntity: Name: NameFull: Mann CW – PersonEntity: Name: NameFull: Mehlmann JF – PersonEntity: Name: NameFull: Rogers JF – PersonEntity: Name: NameFull: Shanno LK – PersonEntity: Name: NameFull: Adams WR – PersonEntity: Name: NameFull: Tio CO – PersonEntity: Name: NameFull: Wrobel JE IsPartOfRelationships: – BibEntity: Dates: – D: 09 M: 04 Text: 2009 Apr 09 Type: published Y: 2009 Identifiers: – Type: issn-electronic Value: 1520-4804 Numbering: – Type: volume Value: 52 – Type: issue Value: 7 Titles: – TitleFull: Journal of medicinal chemistry Type: main |
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