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Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists.

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Title: Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists.
Authors: Kollmann CS; GlaxoSmithKline, Platform Technology & Science, MDR Boston, 830 Winter Street, Waltham, MA 02451, USA., Bai X; GlaxoSmithKline, Platform Technology & Science, MDR Boston, 830 Winter Street, Waltham, MA 02451, USA., Tsai CH; GlaxoSmithKline, Platform Technology & Science, MDR Boston, 830 Winter Street, Waltham, MA 02451, USA., Yang H; GlaxoSmithKline, Platform Technology & Science, MDR Boston, 830 Winter Street, Waltham, MA 02451, USA., Lind KE; GlaxoSmithKline, Platform Technology & Science, MDR Boston, 830 Winter Street, Waltham, MA 02451, USA., Skinner SR; GlaxoSmithKline, Platform Technology & Science, MDR Boston, 830 Winter Street, Waltham, MA 02451, USA., Zhu Z; GlaxoSmithKline, Platform Technology & Science, MDR Boston, 830 Winter Street, Waltham, MA 02451, USA., Israel DI; GlaxoSmithKline, Platform Technology & Science, MDR Boston, 830 Winter Street, Waltham, MA 02451, USA., Cuozzo JW; GlaxoSmithKline, Platform Technology & Science, MDR Boston, 830 Winter Street, Waltham, MA 02451, USA., Morgan BA; GlaxoSmithKline, Platform Technology & Science, MDR Boston, 830 Winter Street, Waltham, MA 02451, USA., Yuki K; Immune Disease Institute, Children's Hospital Boston, Harvard Medical School, Program in Cellular and Molecular Medicine, Department of Biological Chemistry and Molecular Pharmacology, 3 Blackfan Circle, Rm. 3100, Boston, MA 02115, USA., Xie C; Immune Disease Institute, Children's Hospital Boston, Harvard Medical School, Program in Cellular and Molecular Medicine, Department of Biological Chemistry and Molecular Pharmacology, 3 Blackfan Circle, Rm. 3100, Boston, MA 02115, USA., Springer TA; Immune Disease Institute, Children's Hospital Boston, Harvard Medical School, Program in Cellular and Molecular Medicine, Department of Biological Chemistry and Molecular Pharmacology, 3 Blackfan Circle, Rm. 3100, Boston, MA 02115, USA., Shimaoka M; Immune Disease Institute, Children's Hospital Boston, Harvard Medical School, Program in Cellular and Molecular Medicine, Department of Biological Chemistry and Molecular Pharmacology, 3 Blackfan Circle, Rm. 3100, Boston, MA 02115, USA., Evindar G; GlaxoSmithKline, Platform Technology & Science, MDR Boston, 830 Winter Street, Waltham, MA 02451, USA. Electronic address: ghotas.x.evindar@gsk.com.
Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2014 Apr 01; Vol. 22 (7), pp. 2353-65. Date of Electronic Publication: 2014 Feb 07.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists.
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  Data: <searchLink fieldCode="AU" term="%22Kollmann+CS%22">Kollmann CS</searchLink>; GlaxoSmithKline, Platform Technology & Science, MDR Boston, 830 Winter Street, Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Bai+X%22">Bai X</searchLink>; GlaxoSmithKline, Platform Technology & Science, MDR Boston, 830 Winter Street, Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Tsai+CH%22">Tsai CH</searchLink>; GlaxoSmithKline, Platform Technology & Science, MDR Boston, 830 Winter Street, Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Yang+H%22">Yang H</searchLink>; GlaxoSmithKline, Platform Technology & Science, MDR Boston, 830 Winter Street, Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Lind+KE%22">Lind KE</searchLink>; GlaxoSmithKline, Platform Technology & Science, MDR Boston, 830 Winter Street, Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Skinner+SR%22">Skinner SR</searchLink>; GlaxoSmithKline, Platform Technology & Science, MDR Boston, 830 Winter Street, Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+Z%22">Zhu Z</searchLink>; GlaxoSmithKline, Platform Technology & Science, MDR Boston, 830 Winter Street, Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Israel+DI%22">Israel DI</searchLink>; GlaxoSmithKline, Platform Technology & Science, MDR Boston, 830 Winter Street, Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Cuozzo+JW%22">Cuozzo JW</searchLink>; GlaxoSmithKline, Platform Technology & Science, MDR Boston, 830 Winter Street, Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Morgan+BA%22">Morgan BA</searchLink>; GlaxoSmithKline, Platform Technology & Science, MDR Boston, 830 Winter Street, Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Yuki+K%22">Yuki K</searchLink>; Immune Disease Institute, Children's Hospital Boston, Harvard Medical School, Program in Cellular and Molecular Medicine, Department of Biological Chemistry and Molecular Pharmacology, 3 Blackfan Circle, Rm. 3100, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Xie+C%22">Xie C</searchLink>; Immune Disease Institute, Children's Hospital Boston, Harvard Medical School, Program in Cellular and Molecular Medicine, Department of Biological Chemistry and Molecular Pharmacology, 3 Blackfan Circle, Rm. 3100, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Springer+TA%22">Springer TA</searchLink>; Immune Disease Institute, Children's Hospital Boston, Harvard Medical School, Program in Cellular and Molecular Medicine, Department of Biological Chemistry and Molecular Pharmacology, 3 Blackfan Circle, Rm. 3100, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Shimaoka+M%22">Shimaoka M</searchLink>; Immune Disease Institute, Children's Hospital Boston, Harvard Medical School, Program in Cellular and Molecular Medicine, Department of Biological Chemistry and Molecular Pharmacology, 3 Blackfan Circle, Rm. 3100, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Evindar+G%22">Evindar G</searchLink>; GlaxoSmithKline, Platform Technology & Science, MDR Boston, 830 Winter Street, Waltham, MA 02451, USA. Electronic address: ghotas.x.evindar@gsk.com.
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