U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells.
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| Title: | U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells. |
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| Authors: | Smutny T; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05, Hradec Kralove, Czech Republic., Bitman M, Urban M, Dubecka M, Vrzal R, Dvorak Z, Pavek P |
| Source: | Archives of toxicology [Arch Toxicol] 2014 Dec; Vol. 88 (12), pp. 2243-59. Date of Electronic Publication: 2014 May 14. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 24819614 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Smutny+T%22">Smutny T</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Bitman+M%22">Bitman M</searchLink><br /><searchLink fieldCode="AU" term="%22Urban+M%22">Urban M</searchLink><br /><searchLink fieldCode="AU" term="%22Dubecka+M%22">Dubecka M</searchLink><br /><searchLink fieldCode="AU" term="%22Vrzal+R%22">Vrzal R</searchLink><br /><searchLink fieldCode="AU" term="%22Dvorak+Z%22">Dvorak Z</searchLink><br /><searchLink fieldCode="AU" term="%22Pavek+P%22">Pavek P</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220417615%22">Archives of toxicology</searchLink> [Arch Toxicol] 2014 Dec; Vol. 88 (12), pp. 2243-59. <i>Date of Electronic Publication: </i>2014 May 14. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer-Verlag%22">Springer-Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0417615 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0738 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203405761%22">03405761 </searchLink><i>NLM ISO Abbreviation: </i>Arch Toxicol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=24819614 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00204-014-1254-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 2243 Titles: – TitleFull: U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Smutny T – PersonEntity: Name: NameFull: Bitman M – PersonEntity: Name: NameFull: Urban M – PersonEntity: Name: NameFull: Dubecka M – PersonEntity: Name: NameFull: Vrzal R – PersonEntity: Name: NameFull: Dvorak Z – PersonEntity: Name: NameFull: Pavek P IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: 2014 Dec Type: published Y: 2014 Identifiers: – Type: issn-electronic Value: 1432-0738 Numbering: – Type: volume Value: 88 – Type: issue Value: 12 Titles: – TitleFull: Archives of toxicology Type: main |
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