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R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia.

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Title: R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia.
Authors: Slattery CF; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK., Beck JA; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK., Harper L; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK., Adamson G; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK., Abdi Z; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK., Uphill J; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK., Campbell T; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK., Druyeh R; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK., Mahoney CJ; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK., Rohrer JD; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK., Kenny J; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK., Lowe J; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK., Leung KK; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK., Barnes J; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK., Clegg SL; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK., Blair M; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK., Nicholas JM; Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK., Guerreiro RJ; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK., Rowe JB; Department of Clinical Neurosciences, Cambridge University, UK., Ponto C; Department of Neurology, Clinical Dementia Center, Georg-August University Göttingen, Göttingen, Germany., Zerr I; Department of Neurology, Clinical Dementia Center, Georg-August University Göttingen, Göttingen, Germany., Kretzschmar H; Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Munich, Germany., Gambetti P; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA., Crutch SJ; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK., Warren JD; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK., Rossor MN; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK., Fox NC; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK., Collinge J; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK., Schott JM; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK., Mead S; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK. Electronic address: s.mead@prion.ucl.ac.uk.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2014 Nov; Vol. 10 (6), pp. 602-608.e4. Date of Electronic Publication: 2014 Aug 23.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
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  Data: R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia.
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  Data: <searchLink fieldCode="AU" term="%22Slattery+CF%22">Slattery CF</searchLink>; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Beck+JA%22">Beck JA</searchLink>; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Harper+L%22">Harper L</searchLink>; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Adamson+G%22">Adamson G</searchLink>; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Abdi+Z%22">Abdi Z</searchLink>; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Uphill+J%22">Uphill J</searchLink>; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Campbell+T%22">Campbell T</searchLink>; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Druyeh+R%22">Druyeh R</searchLink>; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Mahoney+CJ%22">Mahoney CJ</searchLink>; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Rohrer+JD%22">Rohrer JD</searchLink>; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Kenny+J%22">Kenny J</searchLink>; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Lowe+J%22">Lowe J</searchLink>; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Leung+KK%22">Leung KK</searchLink>; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Barnes+J%22">Barnes J</searchLink>; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Clegg+SL%22">Clegg SL</searchLink>; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Blair+M%22">Blair M</searchLink>; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Nicholas+JM%22">Nicholas JM</searchLink>; Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Guerreiro+RJ%22">Guerreiro RJ</searchLink>; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Rowe+JB%22">Rowe JB</searchLink>; Department of Clinical Neurosciences, Cambridge University, UK.<br /><searchLink fieldCode="AU" term="%22Ponto+C%22">Ponto C</searchLink>; Department of Neurology, Clinical Dementia Center, Georg-August University Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Zerr+I%22">Zerr I</searchLink>; Department of Neurology, Clinical Dementia Center, Georg-August University Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Kretzschmar+H%22">Kretzschmar H</searchLink>; Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Gambetti+P%22">Gambetti P</searchLink>; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Crutch+SJ%22">Crutch SJ</searchLink>; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Warren+JD%22">Warren JD</searchLink>; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Rossor+MN%22">Rossor MN</searchLink>; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Fox+NC%22">Fox NC</searchLink>; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Collinge+J%22">Collinge J</searchLink>; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Schott+JM%22">Schott JM</searchLink>; Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Mead+S%22">Mead S</searchLink>; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK. Electronic address: s.mead@prion.ucl.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2014 Nov; Vol. 10 (6), pp. 602-608.e4. <i>Date of Electronic Publication: </i>2014 Aug 23.
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