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Designing a mutant CCL2-HSA chimera with high glycosaminoglycan-binding affinity and selectivity.

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Title: Designing a mutant CCL2-HSA chimera with high glycosaminoglycan-binding affinity and selectivity.
Authors: Gerlza T; Karl-Franzens-University Graz, Institute of Pharmaceutical Sciences, Universitätsplatz 1, A-8010 Graz, Austria., Winkler S; Karl-Franzens-University Graz, Institute of Pharmaceutical Sciences, Universitätsplatz 1, A-8010 Graz, Austria., Atlic A; VTU Technology, Parkring 18, A-8074 Grambach/Graz, Austria., Zankl C; Karl-Franzens-University Graz, Institute of Pharmaceutical Sciences, Universitätsplatz 1, A-8010 Graz, Austria., Konya V; Medizinische Universität Graz, Institute of Experimental and Clinical Pharmacology, Universitätsplatz 4, A-8010 Graz, Austria., Kitic N; Karl-Franzens-University Graz, Institute of Pharmaceutical Sciences, Universitätsplatz 1, A-8010 Graz, Austria., Strutzmann E; Karl-Franzens-University Graz, Institute of Pharmaceutical Sciences, Universitätsplatz 1, A-8010 Graz, Austria., Knebl K; ProtAffin Biotechnologie AG, Reininghausstrasse 13a, A-8020 Graz, Austria., Adage T; ProtAffin Biotechnologie AG, Reininghausstrasse 13a, A-8020 Graz, Austria., Heinemann A; Medizinische Universität Graz, Institute of Experimental and Clinical Pharmacology, Universitätsplatz 4, A-8010 Graz, Austria., Weis R; VTU Technology, Parkring 18, A-8074 Grambach/Graz, Austria., Kungl AJ; Karl-Franzens-University Graz, Institute of Pharmaceutical Sciences, Universitätsplatz 1, A-8010 Graz, Austria ProtAffin Biotechnologie AG, Reininghausstrasse 13a, A-8020 Graz, Austria Antagonis Biotherapeutics, Strasserhofweg 77a, A-8045 Graz, Austria andreas.kungl@uni-graz.at.
Source: Protein engineering, design & selection : PEDS [Protein Eng Des Sel] 2015 Aug; Vol. 28 (8), pp. 231-40. Date of Electronic Publication: 2015 May 11.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101186484 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1741-0134 (Electronic) Linking ISSN: 17410126 NLM ISO Abbreviation: Protein Eng Des Sel Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1741-0134
DOI:10.1093/protein/gzv025