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Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT).

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Title: Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT).
Authors: Yang H; MDR (Molecular Discovery Research) Boston, Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States., Medeiros PF; MDR (Molecular Discovery Research) Boston, Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States., Raha K; Computational and Structural Chemistry, Platform Technology and Science, Biological Reagents and Assay Development, Platform Technology and Science, Oncology Research, and Screening and Compound Profiling, Platform Technology and Science, GlaxoSmithKline , 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Elkins P; Computational and Structural Chemistry, Platform Technology and Science, Biological Reagents and Assay Development, Platform Technology and Science, Oncology Research, and Screening and Compound Profiling, Platform Technology and Science, GlaxoSmithKline , 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Lind KE; MDR (Molecular Discovery Research) Boston, Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States., Lehr R; Computational and Structural Chemistry, Platform Technology and Science, Biological Reagents and Assay Development, Platform Technology and Science, Oncology Research, and Screening and Compound Profiling, Platform Technology and Science, GlaxoSmithKline , 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Adams ND; Computational and Structural Chemistry, Platform Technology and Science, Biological Reagents and Assay Development, Platform Technology and Science, Oncology Research, and Screening and Compound Profiling, Platform Technology and Science, GlaxoSmithKline , 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Burgess JL; Computational and Structural Chemistry, Platform Technology and Science, Biological Reagents and Assay Development, Platform Technology and Science, Oncology Research, and Screening and Compound Profiling, Platform Technology and Science, GlaxoSmithKline , 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Schmidt SJ; Computational and Structural Chemistry, Platform Technology and Science, Biological Reagents and Assay Development, Platform Technology and Science, Oncology Research, and Screening and Compound Profiling, Platform Technology and Science, GlaxoSmithKline , 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Knight SD; Computational and Structural Chemistry, Platform Technology and Science, Biological Reagents and Assay Development, Platform Technology and Science, Oncology Research, and Screening and Compound Profiling, Platform Technology and Science, GlaxoSmithKline , 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Auger KR; Computational and Structural Chemistry, Platform Technology and Science, Biological Reagents and Assay Development, Platform Technology and Science, Oncology Research, and Screening and Compound Profiling, Platform Technology and Science, GlaxoSmithKline , 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Schaber MD; Computational and Structural Chemistry, Platform Technology and Science, Biological Reagents and Assay Development, Platform Technology and Science, Oncology Research, and Screening and Compound Profiling, Platform Technology and Science, GlaxoSmithKline , 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Franklin GJ; MDR (Molecular Discovery Research) Boston, Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States., Ding Y; MDR (Molecular Discovery Research) Boston, Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States., DeLorey JL; MDR (Molecular Discovery Research) Boston, Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States., Centrella PA; MDR (Molecular Discovery Research) Boston, Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States., Mataruse S; MDR (Molecular Discovery Research) Boston, Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States., Skinner SR; MDR (Molecular Discovery Research) Boston, Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States., Clark MA; MDR (Molecular Discovery Research) Boston, Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States., Cuozzo JW; MDR (Molecular Discovery Research) Boston, Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States., Evindar G; MDR (Molecular Discovery Research) Boston, Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2015 Mar 20; Vol. 6 (5), pp. 531-6. Date of Electronic Publication: 2015 Mar 20 (Print Publication: 2015).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1948-5875
DOI:10.1021/acsmedchemlett.5b00025