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Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction.

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Title: Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction.
Authors: Pettersson M; Department of Chemistry and Molecular Biology, University of Gothenburg, 412 96, Gothenburg, Sweden., Quant M; Department of Chemistry and Molecular Biology, University of Gothenburg, 412 96, Gothenburg, Sweden., Min J; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee, 38105, United States of America., Iconaru L; Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee, 38105, United States of America., Kriwacki RW; Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee, 38105, United States of America., Waddell MB; Molecular Interaction Analysis Shared Resource, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee, 38105, United States of America., Guy RK; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee, 38105, United States of America., Luthman K; Department of Chemistry and Molecular Biology, University of Gothenburg, 412 96, Gothenburg, Sweden., Grøtli M; Department of Chemistry and Molecular Biology, University of Gothenburg, 412 96, Gothenburg, Sweden.
Source: PloS one [PLoS One] 2015 Oct 01; Vol. 10 (10), pp. e0137867. Date of Electronic Publication: 2015 Oct 01 (Print Publication: 2015).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1932-6203
DOI:10.1371/journal.pone.0137867