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Conjugation of mono and di-GalNAc sugars enhances the potency of antisense oligonucleotides via ASGR mediated delivery to hepatocytes.

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Bibliographic Details
Title:	Conjugation of mono and di-GalNAc sugars enhances the potency of antisense oligonucleotides via ASGR mediated delivery to hepatocytes.
Authors:	Kinberger GA; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, United States., Prakash TP; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, United States., Yu J; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, United States., Vasquez G; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, United States., Low A; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, United States., Chappell A; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, United States., Schmidt K; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, United States., Murray HM; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, United States., Gaus H; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, United States., Swayze EE; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, United States., Seth PP; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, United States. Electronic address: pseth@ionisph.com.
Source:	Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Aug 01; Vol. 26 (15), pp. 3690-3. Date of Electronic Publication: 2016 May 28.
Publication Type:	Journal Article
Journal Info:	Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database:	MEDLINE Ultimate

Description
ISSN:	1464-3405
DOI:	10.1016/j.bmcl.2016.05.084