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SMN deficiency in severe models of spinal muscular atrophy causes widespread intron retention and DNA damage.

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Title: SMN deficiency in severe models of spinal muscular atrophy causes widespread intron retention and DNA damage.
Authors: Jangi M; Computational Biology & Genomics, Biogen, Cambridge, MA 02142., Fleet C; Computational Biology & Genomics, Biogen, Cambridge, MA 02142., Cullen P; Computational Biology & Genomics, Biogen, Cambridge, MA 02142., Gupta SV; Computational Biology & Genomics, Biogen, Cambridge, MA 02142., Mekhoubad S; Stem Cell Research, Biogen, Cambridge, MA 02142., Chiao E; Stem Cell Research, Biogen, Cambridge, MA 02142., Allaire N; Computational Biology & Genomics, Biogen, Cambridge, MA 02142., Bennett CF; Neuroscience Drug Discovery, Ionis Pharmaceuticals, Carlsbad, CA 92008., Rigo F; Neuroscience Drug Discovery, Ionis Pharmaceuticals, Carlsbad, CA 92008., Krainer AR; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724., Hurt JA; Computational Biology & Genomics, Biogen, Cambridge, MA 02142., Carulli JP; Computational Biology & Genomics, Biogen, Cambridge, MA 02142; john.carulli@biogen.com john.staropoli@biogen.com., Staropoli JF; Rare Disease, Biogen, Cambridge, MA 02142 john.carulli@biogen.com john.staropoli@biogen.com.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Mar 21; Vol. 114 (12), pp. E2347-E2356. Date of Electronic Publication: 2017 Mar 07.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: SMN deficiency in severe models of spinal muscular atrophy causes widespread intron retention and DNA damage.
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  Data: <searchLink fieldCode="AU" term="%22Jangi+M%22">Jangi M</searchLink>; Computational Biology & Genomics, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Fleet+C%22">Fleet C</searchLink>; Computational Biology & Genomics, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Cullen+P%22">Cullen P</searchLink>; Computational Biology & Genomics, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Gupta+SV%22">Gupta SV</searchLink>; Computational Biology & Genomics, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Mekhoubad+S%22">Mekhoubad S</searchLink>; Stem Cell Research, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Chiao+E%22">Chiao E</searchLink>; Stem Cell Research, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Allaire+N%22">Allaire N</searchLink>; Computational Biology & Genomics, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Bennett+CF%22">Bennett CF</searchLink>; Neuroscience Drug Discovery, Ionis Pharmaceuticals, Carlsbad, CA 92008.<br /><searchLink fieldCode="AU" term="%22Rigo+F%22">Rigo F</searchLink>; Neuroscience Drug Discovery, Ionis Pharmaceuticals, Carlsbad, CA 92008.<br /><searchLink fieldCode="AU" term="%22Krainer+AR%22">Krainer AR</searchLink>; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.<br /><searchLink fieldCode="AU" term="%22Hurt+JA%22">Hurt JA</searchLink>; Computational Biology & Genomics, Biogen, Cambridge, MA 02142.<br /><searchLink fieldCode="AU" term="%22Carulli+JP%22">Carulli JP</searchLink>; Computational Biology & Genomics, Biogen, Cambridge, MA 02142; john.carulli@biogen.com john.staropoli@biogen.com.<br /><searchLink fieldCode="AU" term="%22Staropoli+JF%22">Staropoli JF</searchLink>; Rare Disease, Biogen, Cambridge, MA 02142 john.carulli@biogen.com john.staropoli@biogen.com.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2017 Mar 21; Vol. 114 (12), pp. E2347-E2356. <i>Date of Electronic Publication: </i>2017 Mar 07.
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