SMN deficiency in severe models of spinal muscular atrophy causes widespread intron retention and DNA damage.
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| Title: | SMN deficiency in severe models of spinal muscular atrophy causes widespread intron retention and DNA damage. |
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| Authors: | Jangi M; Computational Biology & Genomics, Biogen, Cambridge, MA 02142., Fleet C; Computational Biology & Genomics, Biogen, Cambridge, MA 02142., Cullen P; Computational Biology & Genomics, Biogen, Cambridge, MA 02142., Gupta SV; Computational Biology & Genomics, Biogen, Cambridge, MA 02142., Mekhoubad S; Stem Cell Research, Biogen, Cambridge, MA 02142., Chiao E; Stem Cell Research, Biogen, Cambridge, MA 02142., Allaire N; Computational Biology & Genomics, Biogen, Cambridge, MA 02142., Bennett CF; Neuroscience Drug Discovery, Ionis Pharmaceuticals, Carlsbad, CA 92008., Rigo F; Neuroscience Drug Discovery, Ionis Pharmaceuticals, Carlsbad, CA 92008., Krainer AR; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724., Hurt JA; Computational Biology & Genomics, Biogen, Cambridge, MA 02142., Carulli JP; Computational Biology & Genomics, Biogen, Cambridge, MA 02142; john.carulli@biogen.com john.staropoli@biogen.com., Staropoli JF; Rare Disease, Biogen, Cambridge, MA 02142 john.carulli@biogen.com john.staropoli@biogen.com. |
| Source: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Mar 21; Vol. 114 (12), pp. E2347-E2356. Date of Electronic Publication: 2017 Mar 07. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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