Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.

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Title: Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.
Authors: Spracklen CN; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Chen P; Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, Singapore.; Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, China., Kim YJ; Division of Structural and Functional Genomics, Center for Genome Science, Korean National Institute of Health, Osong, Chungchungbuk-do, South Korea., Wang X; Life Sciences Institute, National University of Singapore, Singapore, Singapore., Cai H; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Li S; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Long J; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Wu Y; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Wang YX; Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Takeuchi F; National Center for Global Health and Medicine, Tokyo, Japan., Wu JY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; School of Chinese Medicine, China Medical University, Taichung, Taiwan., Jung KJ; Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea., Hu C; Shanghai Diabetes Institute, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China., Akiyama K; National Center for Global Health and Medicine, Tokyo, Japan., Zhang Y; Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China., Moon S; Division of Structural and Functional Genomics, Center for Genome Science, Korean National Institute of Health, Osong, Chungchungbuk-do, South Korea., Johnson TA; Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Li H; Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China., Dorajoo R; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., He M; Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China., Cannon ME; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Roman TS; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Salfati E; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Lin KH; Department of Ophthalmology, Taichung Veterans General Hospital, Taichung, Taiwan., Guo X; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA., Sheu WHH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; School of Medicine, National Defense Medical Center, Taipei, Taiwan.; Institute of Medical Technology, National Chung-Hsing University, Taichung, Taiwan., Absher D; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Adair LS; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA., Assimes TL; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Aung T; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Duke-NUS Medical School Singapore, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Cai Q; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Chang LC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chen CH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; School of Chinese Medicine, China Medical University, Taichung, Taiwan., Chien LH; Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan., Chuang LM; Division of Endocrinology & Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; College of Medicine, National Taiwan University, Taipei, Taiwan.; Institute of Preventive Medicine, School of Public Health, National Taiwan University, Taipei, Taiwan., Chuang SC; Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan., Du S; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.; Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA., Fan Q; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Fann CSJ; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Feranil AB; USC-Office of Population Studies Foundation, Inc, University of San Carlos, Cebu City, Philippines.; Department of Anthropology, Sociology, and History, University of San Carlos, Cebu City, Philippines., Friedlander Y; Unit of Epidemiology, Hebrew University-Hadassah Braun School of Public Health, Jerusalem, Israel., Gordon-Larsen P; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.; Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA., Gu D; Department of Epidemiology and Population Genetics, Fuwai Hospital, Beijing, China., Gui L; Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China., Guo Z; Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China., Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore., Hixson J; Human Genetics Center, University of Texas School of Public Health, Houston, TX, USA., Hou X; Shanghai Diabetes Institute, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China., Hsiung CA; Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan., Hu Y; Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China., Hwang MY; Division of Structural and Functional Genomics, Center for Genome Science, Korean National Institute of Health, Osong, Chungchungbuk-do, South Korea., Hwu CM; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Isono M; National Center for Global Health and Medicine, Tokyo, Japan., Juang JJ; College of Medicine, National Taiwan University, Taipei, Taiwan.; Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Khor CC; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Department of Biochemistry, National University of Singapore, Singapore, Singapore., Kim YK; Division of Structural and Functional Genomics, Center for Genome Science, Korean National Institute of Health, Osong, Chungchungbuk-do, South Korea., Koh WP; Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, Singapore.; Duke-NUS Medical School Singapore, Singapore, Singapore., Kubo M; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Lee IT; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; School of Medicine, Chung Shan Medical University, Taichung, Taiwan., Lee SJ; Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea., Lee WJ; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Social Work, Tunghai University, Taichung, Taiwan., Liang KW; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Medicine, China Medical University, Taichung, Taiwan., Lim B; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Lim SH; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Liu J; Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, Singapore.; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Nabika T; Department of Functional Pathology, Shimane University School of Medicine, Izumo, Japan., Pan WH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Peng H; Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China., Quertermous T; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Sabanayagam C; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Duke-NUS Medical School Singapore, Singapore, Singapore., Sandow K; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA., Shi J; Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center and Shanghai Industrial Technology Institute, Shanghai, China., Sun L; Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China., Tan PC; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Tan SP; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Taylor KD; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA., Teo YY; Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, Singapore.; Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore, Singapore.; Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore., Toh SA; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tsunoda T; Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan., van Dam RM; Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, Singapore., Wang A; Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China., Wang F; Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China., Wang J; Shanghai Diabetes Institute, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China., Wei WB; Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Capital Medical University, Beijing, China., Xiang YB; Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China., Yao J; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA., Yuan JM; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.; Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA., Zhang R; Shanghai Diabetes Institute, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China., Zhao W; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Duke-NUS Medical School Singapore, Singapore, Singapore., Chen YI; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA., Rich SS; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Rotter JI; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA., Wang TD; College of Medicine, National Taiwan University, Taipei, Taiwan.; Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Wu T; Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China., Lin X; Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China., Han BG; Center for Genome Science, Korean National Institute of Health, Osong, Chungchungbuk-do, South Korea., Tanaka T; Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Cho YS; Department of Biomedical Science, Hallym University, Chuncheon, South Korea., Katsuya T; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan., Jia W; Shanghai Diabetes Institute, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China., Jee SH; Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea., Chen YT; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Kato N; National Center for Global Health and Medicine, Tokyo, Japan., Jonas JB; Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.; Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, Germany., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Duke-NUS Medical School Singapore, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Shu XO; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA., He J; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Duke-NUS Medical School Singapore, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Huang W; Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center and Shanghai Industrial Technology Institute, Shanghai, China., Kim BJ; Division of Structural and Functional Genomics, Center for Genome Science, Korean National Institute of Health, Osong, Chungchungbuk-do, South Korea., Tai ES; Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, Singapore.; Duke-NUS Medical School Singapore, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Sim X; Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, Singapore.
Source: Human molecular genetics [Hum Mol Genet] 2017 May 01; Vol. 26 (9), pp. 1770-1784.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1460-2083
DOI:10.1093/hmg/ddx062