The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-d-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-d-Aspartate Receptors.

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Title: The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-d-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-d-Aspartate Receptors.
Authors: Strong KL; Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States., Epplin MP; Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States., Bacsa J; Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States., Butch CJ; Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.; Earth-Life Science Institute, Tokyo Institute of Technology , Meguro-ku, Tokyo Japan., Burger PB; Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States., Menaldino DS; Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States., Traynelis SF; Department of Pharmacology, Emory University , 1510 Clifton Road, Atlanta, Georgia 30322, United States., Liotta DC; Department of Pharmacology, Emory University , 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2017 Jul 13; Vol. 60 (13), pp. 5556-5585. Date of Electronic Publication: 2017 Jun 26.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.7b00239