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Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate.

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Title: Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate.
Authors: Zhang YK; Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle, Palo Alto, California 94303, United States., Plattner JJ; Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle, Palo Alto, California 94303, United States., Easom EE; Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle, Palo Alto, California 94303, United States., Jacobs RT; Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle, Palo Alto, California 94303, United States., Guo D; Department of Medicine, University of California, San Francisco , Box 0811, San Francisco, California 94143, United States., Freund YR; Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle, Palo Alto, California 94303, United States., Berry P; Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle, Palo Alto, California 94303, United States., Ciaravino V; Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle, Palo Alto, California 94303, United States., Erve JCL; Anacor Pharmaceuticals, Inc. , 1020 E. Meadow Circle, Palo Alto, California 94303, United States., Rosenthal PJ; Department of Medicine, University of California, San Francisco , Box 0811, San Francisco, California 94143, United States., Campo B; Medicines for Malaria Venture, International Center Cointrin , Block G, 20 Route de Pré-Bois, POB 1826, CH - 1215 Geneva, Switzerland., Gamo FJ; Diseases of the Developing World, GlaxoSmithKline , Severo Ochoa 2, 28760, Tres Cantos, Spain., Sanz LM; Diseases of the Developing World, GlaxoSmithKline , Severo Ochoa 2, 28760, Tres Cantos, Spain., Cao J; Shanghai ChemPartner , 998 Ha-lei Road, Zhangjiang High-tech Park, Pudong New Area, Shanghai 201203, China.
Source: Journal of medicinal chemistry [J Med Chem] 2017 Jul 13; Vol. 60 (13), pp. 5889-5908. Date of Electronic Publication: 2017 Jun 29.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.7b00621