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Inhibiting PI3Kβ with AZD8186 Regulates Key Metabolic Pathways in PTEN-Null Tumors.

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Bibliographic Details
Title: Inhibiting PI3Kβ with AZD8186 Regulates Key Metabolic Pathways in PTEN-Null Tumors.
Authors: Lynch JT; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom., Polanska UM; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom., Delpuech O; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom., Hancox U; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Alderley Park, United Kingdom., Trinidad AG; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom., Michopoulos F; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Alderley Park, United Kingdom., Lenaghan C; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Alderley Park, United Kingdom., McEwen R; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom., Bradford J; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Alderley Park, United Kingdom., Polanski R; Department of Oncology and Metabolism, University of Sheffield, Sheffield, South Yorkshire, United Kingdom., Ellston R; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Alderley Park, United Kingdom., Avivar-Valderas A; Discovery Sciences, AstraZeneca, Cambridge, United Kingdom., Pilling J; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Alderley Park, United Kingdom., Staniszewska A; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom., Cumberbatch M; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom., Critchlow SE; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom., Cruzalegui F; Discovery Sciences, AstraZeneca, Cambridge, United Kingdom., Barry ST; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom. Simon.T.Barry@astrazeneca.com.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2017 Dec 15; Vol. 23 (24), pp. 7584-7595. Date of Electronic Publication: 2017 Oct 02.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-17-0676