Field-deployable viral diagnostics using CRISPR-Cas13.

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Bibliographic Details
Title: Field-deployable viral diagnostics using CRISPR-Cas13.
Authors: Myhrvold C; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA. pardis@broadinstitute.org cmyhrvol@broadinstitute.org cfreije@broadinstitute.org.; Center for Systems Biology, Department of Organismal and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA., Freije CA; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA. pardis@broadinstitute.org cmyhrvol@broadinstitute.org cfreije@broadinstitute.org.; Center for Systems Biology, Department of Organismal and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.; Ph.D. Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA., Gootenberg JS; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.; McGovern Institute for Brain Research, MIT, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Science, MIT, Cambridge, MA 02139, USA.; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA., Abudayyeh OO; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, MIT, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Science, MIT, Cambridge, MA 02139, USA.; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.; Department of Health Sciences and Technology, MIT, Cambridge, MA 02139, USA., Metsky HC; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA., Durbin AF; Ph.D. Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA.; Institute for Medical Engineering and Science, MIT, Cambridge, MA 02139, USA., Kellner MJ; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA., Tan AL; Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, FL 33965, USA., Paul LM; Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, FL 33965, USA., Parham LA; Centro de Investigaciones Genética, Instituto de Investigacion en Microbiologia, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras., Garcia KF; Centro de Investigaciones Genética, Instituto de Investigacion en Microbiologia, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras., Barnes KG; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; Center for Systems Biology, Department of Organismal and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.; Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115, USA., Chak B; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; Center for Systems Biology, Department of Organismal and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA., Mondini A; Araraquara Laboratory of Public Health, School of Pharmaceutical Sciences, São Paulo State University, São Paulo, Brazil., Nogueira ML; Laboratorio de Pesquisas em Virologia, Faculdade de Medicina de Sao Jose do Rio Preto, São Paulo, Brazil., Isern S; Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, FL 33965, USA., Michael SF; Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, FL 33965, USA., Lorenzana I; Centro de Investigaciones Genética, Instituto de Investigacion en Microbiologia, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras., Yozwiak NL; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; Center for Systems Biology, Department of Organismal and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA., MacInnis BL; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115, USA., Bosch I; Institute for Medical Engineering and Science, MIT, Cambridge, MA 02139, USA.; Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA., Gehrke L; Ph.D. Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA.; Institute for Medical Engineering and Science, MIT, Cambridge, MA 02139, USA.; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA., Zhang F; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, MIT, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Science, MIT, Cambridge, MA 02139, USA.; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA., Sabeti PC; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA. pardis@broadinstitute.org cmyhrvol@broadinstitute.org cfreije@broadinstitute.org.; Center for Systems Biology, Department of Organismal and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.; Ph.D. Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA.; Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115, USA.; Howard Hughes Medical Institute (HHMI), Chevy Chase, MD 20815, USA.
Source: Science (New York, N.Y.) [Science] 2018 Apr 27; Vol. 360 (6387), pp. 444-448.
Publication Type: Evaluation Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1095-9203
DOI:10.1126/science.aas8836