Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.
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| Title: | Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. |
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| Authors: | Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Kraja AT; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Chasman DI; Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America., Sung YJ; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Ntalla I; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Guo X; Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America., Franceschini N; Epidemiology, University of North Carolina Gilling School of Global Public Health, Chapel Hill, North Carolina, United States of America., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Sim X; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore., Vojinovic D; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Marten J; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom., Musani SK; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America., Li C; Epidemiology and Biostatistics, University of Georgia at Athens College of Public Health, Athens, Georgia, United States of America., Bentley AR; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America., Brown MR; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America., Schwander K; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Richard MA; Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America., Noordam R; Internal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands., Aschard H; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.; Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur, Paris, France., Bartz TM; Cardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, Washington, United States of America., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America., Dorajoo R; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore., Fisher V; Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America., Hartwig FP; Postgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, RS, Brazil.; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom., Horimoto ARVR; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, Brazil., Lohman KK; Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Manning AK; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America., Rankinen T; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America., Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Tajuddin SM; Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America., Wojczynski MK; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Alver M; Estonian Genome Center, University of Tartu, Tartu, Estonia., Boissel M; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France., Cai Q; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America., Campbell A; Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom., Chai JF; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore., Chen X; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden., Divers J; Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Gao C; Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Goel A; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom., Hagemeijer Y; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Harris SE; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.; Medical Genetics Section, Centre for Genomic and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, United Kingdom., He M; Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Hsu FC; Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.; University of Tampere, Tampere, Finland., Kasturiratne A; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Komulainen P; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Kühnel B; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Laguzzi F; Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Luan J; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom., Matoba N; Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Padmanabhan S; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom., Riaz M; Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom., Rueedi R; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Instititute of Bioinformatics, Lausanne, Switzerland., Robino A; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy., Said MA; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Scott RA; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom., Sofer T; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, United States of America., Stančáková A; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Takeuchi F; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Tayo BO; Department of Public Health Sciences, Loyola University Chicago, Maywood, Illinois, United States of America., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Varga TV; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden., Vitart V; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom., Wang Y; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America., Ware EB; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America., Warren HR; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, London, United Kingdom., Weiss S; Interfaculty Institute for Genetics and Functional genomics, University Medicine Ernst Moritz Arndt University Greifsald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Wen W; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America., Yanek LR; Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.; Department of Cardiology, Ealing Hospital, Middlesex, United Kingdom., Zhao JH; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom., Afaq S; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom., Amin N; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Amini M; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Arking DE; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Aung T; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Boerwinkle E; Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, Texas, United States of America.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America., Borecki I; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Broeckel U; Section of Genomic Pediatrics, Department of Pediatrics, Medicine and Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America., Brown M; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, London, United Kingdom., Brumat M; Department of Medical Sciences, University of Trieste, Trieste, Italy., Burke GL; Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Canouil M; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France., Chakravarti A; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Charumathi S; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Ida Chen YD; Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America., Connell JM; Ninewells Hospital & Medical School, University of Dundee, Dundee, Scotland, United Kingdom., Correa A; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America., de las Fuentes L; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America.; Cardiovascular Division, Department of Medicine, Washington University, St. Louis, Missouri, United States of America., de Mutsert R; Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., de Silva HJ; Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Deng X; Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America., Ding J; Center on Diabetes, Obesity, and Metabolism, Gerontology and Geriatric Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America., Duan Q; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America., Eaton CB; Department of Family Medicine and Epidemiology, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America., Ehret G; Cardiology, Geneva University Hospital, Geneva, Switzerland., Eppinga RN; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Evangelou E; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America., Felix SB; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany., Forouhi NG; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom., Forrester T; The Caribbean Institute for Health Research (CAIHR), University of the West Indies, Mona, Jamaica., Franco OH; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Friedlander Y; Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel., Gandin I; Department of Medical Sciences, University of Trieste, Trieste, Italy., Gao H; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom., Ghanbari M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Gigante B; Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Gu CC; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Gu D; Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Hagenaars SP; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.; Psychology, The University of Edinburgh, Edinburgh, United Kingdom., Hallmans G; Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Västerbotten, Sweden., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America., He J; Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of America.; Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America., Heikkinen S; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Finland., Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore., Hirata M; Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Japan., Howard BV; MedStar Health Research Institute, Hyattsville, Maryland, United States of America.; Center for Clinical and Translational Sciences and Department of Medicine, Georgetown-Howard Universities, Washington, DC, United States of America., Ikram MA; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands., John U; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Institute of Social Medicine and Prevention, University Medicine Greifswald, Greifswald, Germany., Katsuya T; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan., Khor CC; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.; Department of Biochemistry, National University of Singapore, Singapore, Singapore., Kilpeläinen TO; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Environmental Medicine and Public Health, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Koh WP; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Krieger JE; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, Brazil., Kritchevsky SB; Sticht Center for Healthy Aging and Alzheimer's Prevention, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Kubo M; Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Lakka TA; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Langefeld CD; Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Langenberg C; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America., Lehne B; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom., Lewis CE; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States of America., Li Y; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Lin S; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Liu J; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore., Liu J; WHI CCC, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America., Loh M; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore., Louie T; Department of Biostatistics, University of Washington, Seattle, Washington, United States of America., Mägi R; Estonian Genome Center, University of Tartu, Tartu, Estonia., McKenzie CA; The Caribbean Institute for Health Research (CAIHR), University of the West Indies, Mona, Jamaica., Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, Munich, Germany., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, Estonia., Milaneschi Y; Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands., Milani L; Estonian Genome Center, University of Tartu, Tartu, Estonia., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America., Momozawa Y; Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan., Nalls MA; Data Tecnica International, Glen Echo, Maryland, United States of America.; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, United States of America., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom., Sotoodehnia N; Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, Washington, United States of America., Norris JM; Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado, United States of America., O'Connell JR; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America., Palmer ND; Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Perls T; Geriatrics Section, Boston University Medical Center, Boston, Massachusetts, United States of America., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden., Peters A; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Neuherberg, Germany., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America., Poulter N; School of Public Health, Imperial College London, London, London, United Kingdom., Raffel LJ; Division of Genetic and Genomic Medicine, Department of Pediatrics, University of California, Irvine, California, United States of America., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Roll K; Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America., Rose LM; Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America., Rosendaal FR; Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Rotter JI; Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America., Schmidt CO; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Schreiner PJ; Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America., Schupf N; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America., Scott WR; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Sever PS; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Shi Y; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Sidney S; Division of Research, Kaiser Permanente of Northern California, Oakland, California, United States of America., Sims M; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America., Sitlani CM; Cardiovascular Health Research Unit, Medicine, University of Washington, Seattle, Washington, United States of America., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.; Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, United Kingdom., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU, Munich, Germany., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America., Tan NYQ; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Tang H; Department of Genetics, Stanford University, Stanford, California, United States of America., Taylor KD; Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America., Teo YY; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.; Life Sciences Institute, National University of Singapore, Singapore, Singapore.; NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore, Singapore.; Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore., Tham YC; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Turner ST; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America., Uitterlinden AG; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., Vollenweider P; Service of Internal Medicine, Department of Internal Medicine, University Hospital, Lausanne, Switzerland., Waldenberger M; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Wang L; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Wang YX; Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Capital Medical University, Beijing, China.; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Wei WB; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Williams C; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America., Yao J; Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America., Yu C; Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Yuan JM; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America., Zonderman AB; Behavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America., Becker DM; Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America., Bowden DW; Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.; Department of Cardiology, Ealing Hospital, Middlesex, United Kingdom.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Imperial College Healthcare NHS Trust, London, United Kingdom.; MRC-PHE Centre for Environment and Health, Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.; Psychology, The University of Edinburgh, Edinburgh, United Kingdom., Esko T; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts, United States of America., Farrall M; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom., Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden.; Harvard T. H. Chan School of Public Health, Department of Nutrition, Harvard University, Boston, Massachusetts, United States of America., Freedman BI; Nephrology, Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America., Froguel P; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.; Department of Genomics of Common Disease, Imperial College London, London, United Kingdom., Gasparini P; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy.; Department of Medical Sciences, University of Trieste, Trieste, Italy., Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany., Jonas JB; Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Capital Medical University, Beijing, China.; Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany, Germany., Kamatani Y; Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan., Kato N; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Kooner JS; Department of Cardiology, Ealing Hospital, Middlesex, United Kingdom.; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Imperial College Healthcare NHS Trust, London, United Kingdom.; MRC-PHE Centre for Environment and Health, Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom., Kutalik Z; Swiss Instititute of Bioinformatics, Lausanne, Switzerland.; Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Laurie CC; Department of Biostatistics, University of Washington, Seattle, Washington, United States of America., Leander K; Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland., Study LC; Lifelines Cohort, Groningen, The Netherlands., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden., Oldehinkel AJ; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Penninx BWJH; Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands., Polasek O; Department of Public Health, Department of Medicine, University of Split, Split, Croatia.; 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| Corporate Authors: | InterAct Consortium |
| Source: | PloS one [PLoS One] 2018 Jun 18; Vol. 13 (6), pp. e0198166. Date of Electronic Publication: 2018 Jun 18 (Print Publication: 2018). |
| Publication Type: | Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1932-6203 |
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| DOI: | 10.1371/journal.pone.0198166 |
