Mixed-effects association of single cells identifies an expanded effector CD4+ T cell subset in rheumatoid arthritis.
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| Title: | Mixed-effects association of single cells identifies an expanded effector CD4+ T cell subset in rheumatoid arthritis. |
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| Authors: | Fonseka CY; Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Department of Biomedical Informatics, Harvard University, Cambridge, MA 02138, USA.; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA., Rao DA; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Teslovich NC; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Korsunsky I; Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Hannes SK; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Slowikowski K; Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Department of Biomedical Informatics, Harvard University, Cambridge, MA 02138, USA.; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA., Gurish MF; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Donlin LT; Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.; David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA., Lederer JA; Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Weinblatt ME; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Massarotti EM; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Coblyn JS; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Helfgott SM; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Todd DJ; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Bykerk VP; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA.; Division of Rheumatology, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA., Karlson EW; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Ermann J; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Lee YC; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Brenner MB; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Raychaudhuri S; Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. soumya@broadinstitute.org.; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.; Institute of Inflammation and Repair, University of Manchester, Manchester, UK. |
| Source: | Science translational medicine [Sci Transl Med] 2018 Oct 17; Vol. 10 (463). |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.aaq0305 |
