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Mixed-effects association of single cells identifies an expanded effector CD4+ T cell subset in rheumatoid arthritis.

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Title: Mixed-effects association of single cells identifies an expanded effector CD4+ T cell subset in rheumatoid arthritis.
Authors: Fonseka CY; Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Department of Biomedical Informatics, Harvard University, Cambridge, MA 02138, USA.; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA., Rao DA; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Teslovich NC; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Korsunsky I; Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Hannes SK; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Slowikowski K; Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Department of Biomedical Informatics, Harvard University, Cambridge, MA 02138, USA.; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA., Gurish MF; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Donlin LT; Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.; David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA., Lederer JA; Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Weinblatt ME; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Massarotti EM; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Coblyn JS; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Helfgott SM; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Todd DJ; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Bykerk VP; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA.; Division of Rheumatology, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA., Karlson EW; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Ermann J; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Lee YC; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Brenner MB; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Raychaudhuri S; Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. soumya@broadinstitute.org.; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.; Institute of Inflammation and Repair, University of Manchester, Manchester, UK.
Source: Science translational medicine [Sci Transl Med] 2018 Oct 17; Vol. 10 (463).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mixed-effects association of single cells identifies an expanded effector CD4<superscript>+</superscript> T cell subset in rheumatoid arthritis.
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  Data: <searchLink fieldCode="AU" term="%22Fonseka+CY%22">Fonseka CY</searchLink>; Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Department of Biomedical Informatics, Harvard University, Cambridge, MA 02138, USA.; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Rao+DA%22">Rao DA</searchLink>; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Teslovich+NC%22">Teslovich NC</searchLink>; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Korsunsky+I%22">Korsunsky I</searchLink>; Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Hannes+SK%22">Hannes SK</searchLink>; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Slowikowski+K%22">Slowikowski K</searchLink>; Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Department of Biomedical Informatics, Harvard University, Cambridge, MA 02138, USA.; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Gurish+MF%22">Gurish MF</searchLink>; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Donlin+LT%22">Donlin LT</searchLink>; Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.; David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Lederer+JA%22">Lederer JA</searchLink>; Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Weinblatt+ME%22">Weinblatt ME</searchLink>; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Massarotti+EM%22">Massarotti EM</searchLink>; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Coblyn+JS%22">Coblyn JS</searchLink>; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Helfgott+SM%22">Helfgott SM</searchLink>; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Todd+DJ%22">Todd DJ</searchLink>; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Bykerk+VP%22">Bykerk VP</searchLink>; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA.; Division of Rheumatology, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Karlson+EW%22">Karlson EW</searchLink>; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Ermann+J%22">Ermann J</searchLink>; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Lee+YC%22">Lee YC</searchLink>; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Brenner+MB%22">Brenner MB</searchLink>; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Raychaudhuri+S%22">Raychaudhuri S</searchLink>; Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. soumya@broadinstitute.org.; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.; Institute of Inflammation and Repair, University of Manchester, Manchester, UK.
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