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Therapeutic targeting of the RB1 pathway in retinoblastoma with the oncolytic adenovirus VCN-01.

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Title: Therapeutic targeting of the RB1 pathway in retinoblastoma with the oncolytic adenovirus VCN-01.
Authors: Pascual-Pasto G; Institut de Recerca Sant Joan de Deu, Barcelona 08950, Spain.; Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, Barcelona 08950, Spain., Bazan-Peregrino M; VCN Biosciences, Sant Cugat del Valles, Barcelona 08174, Spain., Olaciregui NG; Institut de Recerca Sant Joan de Deu, Barcelona 08950, Spain.; Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, Barcelona 08950, Spain., Restrepo-Perdomo CA; Pathology, Hospital Sant Joan de Deu, Barcelona 08950, Spain., Mato-Berciano A; VCN Biosciences, Sant Cugat del Valles, Barcelona 08174, Spain., Ottaviani D; Institut Curie, CNRS, UMR144, SIREDO Oncology Center, 75248 Paris, France.; Institut Curie, PSL Research University, 75248 Paris, France., Weber K; AnaPath GmbH, Oberbuchsiten 4625, Switzerland., Correa G; Institut de Recerca Sant Joan de Deu, Barcelona 08950, Spain.; Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, Barcelona 08950, Spain., Paco S; Institut de Recerca Sant Joan de Deu, Barcelona 08950, Spain.; Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, Barcelona 08950, Spain., Vila-Ubach M; Institut de Recerca Sant Joan de Deu, Barcelona 08950, Spain.; Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, Barcelona 08950, Spain., Cuadrado-Vilanova M; Institut de Recerca Sant Joan de Deu, Barcelona 08950, Spain.; Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, Barcelona 08950, Spain., Castillo-Ecija H; Institut de Recerca Sant Joan de Deu, Barcelona 08950, Spain.; Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, Barcelona 08950, Spain., Botteri G; Institut de Recerca Sant Joan de Deu, Barcelona 08950, Spain.; Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, Barcelona 08950, Spain., Garcia-Gerique L; Institut de Recerca Sant Joan de Deu, Barcelona 08950, Spain.; Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, Barcelona 08950, Spain., Moreno-Gilabert H; Institut de Recerca Sant Joan de Deu, Barcelona 08950, Spain.; Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, Barcelona 08950, Spain., Gimenez-Alejandre M; VCN Biosciences, Sant Cugat del Valles, Barcelona 08174, Spain., Alonso-Lopez P; VCN Biosciences, Sant Cugat del Valles, Barcelona 08174, Spain., Farrera-Sal M; VCN Biosciences, Sant Cugat del Valles, Barcelona 08174, Spain., Torres-Manjon S; Translational Research Laboratory, IDIBELL-Institut Catala d'Oncologia, 08908, L'Hospitalet de Llobregat, Barcelona, Spain., Ramos-Lozano D; Translational Research Laboratory, IDIBELL-Institut Catala d'Oncologia, 08908, L'Hospitalet de Llobregat, Barcelona, Spain., Moreno R; Translational Research Laboratory, IDIBELL-Institut Catala d'Oncologia, 08908, L'Hospitalet de Llobregat, Barcelona, Spain., Aerts I; Institut Curie, CNRS, UMR144, SIREDO Oncology Center, 75248 Paris, France.; Institut Curie, PSL Research University, 75248 Paris, France., Doz F; Institut Curie, CNRS, UMR144, SIREDO Oncology Center, 75248 Paris, France.; Paris Descartes University, 75006 Paris, France., Cassoux N; Institut Curie, CNRS, UMR144, SIREDO Oncology Center, 75248 Paris, France.; Paris Descartes University, 75006 Paris, France.; Institut Curie, Ophthalmic Oncology, 75248 Paris, France., Chapeaublanc E; Institut Curie, CNRS, UMR144, SIREDO Oncology Center, 75248 Paris, France.; Institut Curie, PSL Research University, 75248 Paris, France., Torrebadell M; Institut de Recerca Sant Joan de Deu, Barcelona 08950, Spain.; Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, Barcelona 08950, Spain., Roldan M; Institut de Recerca Sant Joan de Deu, Barcelona 08950, Spain.; Pathology, Hospital Sant Joan de Deu, Barcelona 08950, Spain., König A; Vivotecnia Research S.L., Tres Cantos, Madrid 28760, Spain., Suñol M; Pathology, Hospital Sant Joan de Deu, Barcelona 08950, Spain., Claverol J; Institut de Recerca Sant Joan de Deu, Barcelona 08950, Spain.; Clinical Trials Unit, Hospital Sant Joan de Deu, Barcelona 08950, Spain., Lavarino C; Institut de Recerca Sant Joan de Deu, Barcelona 08950, Spain.; Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, Barcelona 08950, Spain., Carmen de T; Institut de Recerca Sant Joan de Deu, Barcelona 08950, Spain.; Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, Barcelona 08950, Spain., Fu L; Pediatric Hematology-Oncology, Hospital Escuela Universitario, Tegucigalpa, Honduras., Radvanyi F; Institut Curie, CNRS, UMR144, SIREDO Oncology Center, 75248 Paris, France.; Institut Curie, PSL Research University, 75248 Paris, France., Munier FL; Hôpital Ophtalmique Jules-Gonin, Lausanne 133, Switzerland., Catalá-Mora J; Ophthalmology, Hospital Sant Joan de Deu, Barcelona 08950, Spain., Mora J; Institut de Recerca Sant Joan de Deu, Barcelona 08950, Spain.; Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, Barcelona 08950, Spain., Alemany R; Translational Research Laboratory, IDIBELL-Institut Catala d'Oncologia, 08908, L'Hospitalet de Llobregat, Barcelona, Spain., Cascalló M; VCN Biosciences, Sant Cugat del Valles, Barcelona 08174, Spain., Chantada GL; Institut de Recerca Sant Joan de Deu, Barcelona 08950, Spain.; Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, Barcelona 08950, Spain.; Hospital de Pediatria JP Garrahan, Buenos Aires 1245, Argentina.; CONICET, Buenos Aires 1245, Argentina., Carcaboso AM; Institut de Recerca Sant Joan de Deu, Barcelona 08950, Spain. amontero@fsjd.org.; Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, Barcelona 08950, Spain.
Source: Science translational medicine [Sci Transl Med] 2019 Jan 23; Vol. 11 (476).
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1946-6242
DOI:10.1126/scitranslmed.aat9321