Hypoxic cancer-associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling.

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Title: Hypoxic cancer-associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling.
Authors: Kugeratski FG; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK., Atkinson SJ; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK., Neilson LJ; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK., Lilla S; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK., Knight JRP; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK., Serneels J; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium., Juin A; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK., Ismail S; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK., Bryant DM; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK., Markert EK; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK., Machesky LM; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK., Mazzone M; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium.; Laboratory of Tumor Inflammation and Angiogenesis, Department of Oncology, KU Leuven, 3000 Leuven, Belgium., Sansom OJ; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK., Zanivan S; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK. s.zanivan@beatson.gla.ac.uk.; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK.
Source: Science signaling [Sci Signal] 2019 Feb 05; Vol. 12 (567). Date of Electronic Publication: 2019 Feb 05.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1937-9145
DOI:10.1126/scisignal.aan8247