Design, Synthesis, and Biological Evaluation of a New Series of Carvedilol Derivatives That Protect Sensory Hair Cells from Aminoglycoside-Induced Damage by Blocking the Mechanoelectrical Transducer Channel.
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| Title: | Design, Synthesis, and Biological Evaluation of a New Series of Carvedilol Derivatives That Protect Sensory Hair Cells from Aminoglycoside-Induced Damage by Blocking the Mechanoelectrical Transducer Channel. |
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| Authors: | O'Reilly M, Kirkwood NK, Kenyon EJ, Huckvale R, Cantillon DM; Wellcome Trust Centre for Global Health Research, Brighton and Sussex Medical School , University of Sussex , Falmer , Brighton BN1 9PX , U.K., Waddell SJ; Wellcome Trust Centre for Global Health Research, Brighton and Sussex Medical School , University of Sussex , Falmer , Brighton BN1 9PX , U.K., Ward SE; Medicines Discovery Institute , Cardiff University , Park Place , Cardiff CF10 3AT , U.K., Richardson GP, Kros CJ, Derudas M |
| Source: | Journal of medicinal chemistry [J Med Chem] 2019 Jun 13; Vol. 62 (11), pp. 5312-5329. Date of Electronic Publication: 2019 May 24. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1520-4804 |
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| DOI: | 10.1021/acs.jmedchem.8b01325 |
