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Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

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Title: Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
Authors: Law PJ; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK., Timofeeva M; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK., Fernandez-Rozadilla C; Grupo de Medicina Xenómica, Fundación Pública Galega de Medicina Xenómica, Instituto de Investigación de Santiago, Santiago de Compostela, 15706, Spain.; Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK., Broderick P; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK., Studd J; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK., Fernandez-Tajes J; Wellcome Centre for Human Genetics, McCarthy Group, Roosevelt Drive, Oxford, OX3 7BN, UK., Farrington S; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK., Svinti V; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK., Palles C; Gastrointestinal Cancer Genetics Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK., Orlando G; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK., Sud A; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK., Holroyd A; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK., Penegar S; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK., Theodoratou E; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, UK., Vaughan-Shaw P; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK., Campbell H; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, UK., Zgaga L; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.; Department of Public Health and Primary Care, Institute of Population Health, Trinity College Dublin, University of Dublin, Dublin, D02 PN40, Ireland., Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK., Campbell A; Generation Scotland, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK., Harris S; Generation Scotland, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Deary IJ; Generation Scotland, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Starr J; Generation Scotland, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.; Medical Genetics Section, Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Gatcombe L; Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK., Pinna M; Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK., Briggs S; Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK., Martin L; Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK., Jaeger E; Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK., Sharma-Oates A; Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK., East J; Translational Gastroenterology Unit, Nuffield Department. of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK., Leedham S; Wellcome Centre for Human Genetics, McCarthy Group, Roosevelt Drive, Oxford, OX3 7BN, UK.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Arnold R; Cancer Bioinfomatics Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK., Johnstone E; Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7LE, UK., Wang H; Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7LE, UK., Kerr D; Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK., Kerr R; Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7LE, UK., Maughan T; Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7LE, UK., Kaplan R; Medical Research Council Clinical Trials Unit, Aviation House, 125 Kingsway, London, WC2B 6NH, UK., Al-Tassan N; Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, 11211, Saudi Arabia., Palin K; Department of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland., Hänninen UA; Department of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland., Cajuso T; Department of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland., Tanskanen T; Department of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland., Kondelin J; Department of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland., Kaasinen E; Department of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland., Sarin AP; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00014, Finland., Eriksson JG; Folkhälsan Research Centre, 00250, Helsinki, Finland.; Unit of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, 00014, Finland., Rissanen H; National Institute for Health and Welfare, Helsinki, 00271, Finland., Knekt P; National Institute for Health and Welfare, Helsinki, 00271, Finland., Pukkala E; Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland, and Faculty of Social Sciences, University of Tampere, Tampere, 33014, Finland.; Faculty of Social Sciences, University of Tampere, Tampere, 33014, Finland., Jousilahti P; National Institute for Health and Welfare, Helsinki, 00271, Finland., Salomaa V; National Institute for Health and Welfare, Helsinki, 00271, Finland., Ripatti S; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00014, Finland.; Department of Public Health, University of Helsinki, Helsinki, 00014, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Palotie A; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00014, Finland.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA., Renkonen-Sinisalo L; Department of Surgery, Abdominal Center, Helsinki University Hospital, Helsinki, 00029, Finland., Lepistö A; Department of Surgery, Abdominal Center, Helsinki University Hospital, Helsinki, 00029, Finland., Böhm J; Department of Pathology, Central Finland Central Hospital, Jyväskylä, 40620, Finland., Mecklin JP; Department of Surgery, Jyväskylä Central Hospital, Jyväskylä, 40620, Finland.; Department of Health Sciences, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, 40014, Finland., Buchanan DD; Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, 3010, Australia.; Victorian Comprehensive Cancer Centre, University of Melbourne, Centre for Cancer Research, Parkville, Victoria, 3010, Australia.; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, VIC, 3010, Australia., Win AK; Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC, 3010, Australia., Hopper J; Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC, 3010, Australia., Jenkins ME; Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC, 3010, Australia., Lindor NM; Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ, 85259, USA., Newcomb PA; Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Gallinger S; Mount Sinai Hospital, Lunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, Canada., Duggan D; Translational Genomics Research Institute (TGen), An Affiliate of City of Hope, Phoenix, AZ, 85004, USA., Casey G; Center for Public Health Genomics, University of Virginia, Virginia, VA, 22903, USA., Hoffmann P; Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, 4031, Switzerland.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, 53127, Germany., Nöthen MM; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, 53127, Germany.; Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, 53127, Germany., Jöckel KH; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, 45147, Germany., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK.; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK., Pharoah PDP; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK.; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK., Peto J; Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK., Canzian F; Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany., Swerdlow A; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.; Division of Breast Cancer Research, The Institute of Cancer Research, London, SW3 6JB, UK., Eeles RA; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.; Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK., Kote-Jarai Z; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK., Muir K; Division of Population Health, Health Services Research and Primary Care, University of Manchester, Manchester, M13 9PL, UK.; Warwick Medical School, University of Warwick, Coventry, CV4 7HL, UK., Pashayan N; Department of Applied Health Research, University College London, London, WC1E 7HB, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, Strangeways Laboratory, University of Cambridge, Cambridge, CB1 8RN, UK., Harkin A; Cancer Research UK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow, Glasgow, G61 1BD, UK., Allan K; Cancer Research UK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow, Glasgow, G61 1BD, UK., McQueen J; Cancer Research UK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow, Glasgow, G61 1BD, UK., Paul J; Cancer Research UK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow, Glasgow, G61 1BD, UK., Iveson T; University Hospital Southampton NHS Foundation Trust, Southampton, SO16 6YD, UK., Saunders M; The Christie NHS Foundation Trust, Manchester, M20 4BX, UK., Butterbach K; Division of Clinical Epidemiology and Aging Research, Deutsches Krebsforschungszentrum, 69120, Heidelberg, Germany., Chang-Claude J; Unit of Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.; University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, 20251, Germany., Hoffmeister M; Division of Clinical Epidemiology and Aging Research, Deutsches Krebsforschungszentrum, 69120, Heidelberg, Germany., Brenner H; Division of Clinical Epidemiology and Aging Research, Deutsches Krebsforschungszentrum, 69120, Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, 69120, Germany., Kirac I; Department of Surgical Oncology, University Hospital for Tumours, Sestre milosrdnice University Hospital Centre, Zagreb, 10000, Croatia., Matošević P; Department of Surgery, University Hospital Center Zagreb, 10000, Zagreb, Croatia., Hofer P; Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria., Brezina S; Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria., Gsur A; Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria., Cheadle JP; Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK., Aaltonen LA; Department of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland., Tomlinson I; Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK., Houlston RS; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK. richard.houlston@icr.ac.uk., Dunlop MG; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Corporate Authors: PRACTICAL consortium
Source: Nature communications [Nat Commun] 2019 May 14; Vol. 10 (1), pp. 2154. Date of Electronic Publication: 2019 May 14.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-019-09775-w