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Development and validation of a chiral LC-ESI-MS/MS method for simultaneous determination of the enantiomeric metabolites isosorbide 2-mononitrate and isosorbide 5-mononitrate of isosorbide dinitrate in rat and human plasma.

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Title: Development and validation of a chiral LC-ESI-MS/MS method for simultaneous determination of the enantiomeric metabolites isosorbide 2-mononitrate and isosorbide 5-mononitrate of isosorbide dinitrate in rat and human plasma.
Authors: Patel BD; Department of Drug Metabolism Pharmacokinetics and Bioanalysis, Eurofins Advinus Ltd., 21 & 22, Phase II, Peenya Industrial Area, Bengaluru, 560058, India; Department of Chemistry, PAHER University, Udaipur, Rajasthan, India. Electronic address: BhaveshPatel3@eurofins.com., Pulakundam N; Department of Drug Metabolism Pharmacokinetics and Bioanalysis, Eurofins Advinus Ltd., 21 & 22, Phase II, Peenya Industrial Area, Bengaluru, 560058, India., Gadekar AR; Department of Drug Metabolism Pharmacokinetics and Bioanalysis, Eurofins Advinus Ltd., 21 & 22, Phase II, Peenya Industrial Area, Bengaluru, 560058, India., Raje AA; Department of Drug Metabolism Pharmacokinetics and Bioanalysis, Eurofins Advinus Ltd., 21 & 22, Phase II, Peenya Industrial Area, Bengaluru, 560058, India., Ramanathan V; Department of Drug Metabolism Pharmacokinetics and Bioanalysis, Eurofins Advinus Ltd., 21 & 22, Phase II, Peenya Industrial Area, Bengaluru, 560058, India., Ameta R; Department of Chemistry, PAHER University, Udaipur, Rajasthan, India.
Source: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2019 Sep 10; Vol. 174, pp. 396-405. Date of Electronic Publication: 2019 Jun 05.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-264X
DOI:10.1016/j.jpba.2019.06.007