Development and validation of a chiral LC-ESI-MS/MS method for simultaneous determination of the enantiomeric metabolites isosorbide 2-mononitrate and isosorbide 5-mononitrate of isosorbide dinitrate in rat and human plasma.
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| Title: | Development and validation of a chiral LC-ESI-MS/MS method for simultaneous determination of the enantiomeric metabolites isosorbide 2-mononitrate and isosorbide 5-mononitrate of isosorbide dinitrate in rat and human plasma. |
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| Authors: | Patel BD; Department of Drug Metabolism Pharmacokinetics and Bioanalysis, Eurofins Advinus Ltd., 21 & 22, Phase II, Peenya Industrial Area, Bengaluru, 560058, India; Department of Chemistry, PAHER University, Udaipur, Rajasthan, India. Electronic address: BhaveshPatel3@eurofins.com., Pulakundam N; Department of Drug Metabolism Pharmacokinetics and Bioanalysis, Eurofins Advinus Ltd., 21 & 22, Phase II, Peenya Industrial Area, Bengaluru, 560058, India., Gadekar AR; Department of Drug Metabolism Pharmacokinetics and Bioanalysis, Eurofins Advinus Ltd., 21 & 22, Phase II, Peenya Industrial Area, Bengaluru, 560058, India., Raje AA; Department of Drug Metabolism Pharmacokinetics and Bioanalysis, Eurofins Advinus Ltd., 21 & 22, Phase II, Peenya Industrial Area, Bengaluru, 560058, India., Ramanathan V; Department of Drug Metabolism Pharmacokinetics and Bioanalysis, Eurofins Advinus Ltd., 21 & 22, Phase II, Peenya Industrial Area, Bengaluru, 560058, India., Ameta R; Department of Chemistry, PAHER University, Udaipur, Rajasthan, India. |
| Source: | Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2019 Sep 10; Vol. 174, pp. 396-405. Date of Electronic Publication: 2019 Jun 05. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 31212140 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Development and validation of a chiral LC-ESI-MS/MS method for simultaneous determination of the enantiomeric metabolites isosorbide 2-mononitrate and isosorbide 5-mononitrate of isosorbide dinitrate in rat and human plasma. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Patel+BD%22">Patel BD</searchLink>; Department of Drug Metabolism Pharmacokinetics and Bioanalysis, Eurofins Advinus Ltd., 21 & 22, Phase II, Peenya Industrial Area, Bengaluru, 560058, India; Department of Chemistry, PAHER University, Udaipur, Rajasthan, India. Electronic address: BhaveshPatel3@eurofins.com.<br /><searchLink fieldCode="AU" term="%22Pulakundam+N%22">Pulakundam N</searchLink>; Department of Drug Metabolism Pharmacokinetics and Bioanalysis, Eurofins Advinus Ltd., 21 & 22, Phase II, Peenya Industrial Area, Bengaluru, 560058, India.<br /><searchLink fieldCode="AU" term="%22Gadekar+AR%22">Gadekar AR</searchLink>; Department of Drug Metabolism Pharmacokinetics and Bioanalysis, Eurofins Advinus Ltd., 21 & 22, Phase II, Peenya Industrial Area, Bengaluru, 560058, India.<br /><searchLink fieldCode="AU" term="%22Raje+AA%22">Raje AA</searchLink>; Department of Drug Metabolism Pharmacokinetics and Bioanalysis, Eurofins Advinus Ltd., 21 & 22, Phase II, Peenya Industrial Area, Bengaluru, 560058, India.<br /><searchLink fieldCode="AU" term="%22Ramanathan+V%22">Ramanathan V</searchLink>; Department of Drug Metabolism Pharmacokinetics and Bioanalysis, Eurofins Advinus Ltd., 21 & 22, Phase II, Peenya Industrial Area, Bengaluru, 560058, India.<br /><searchLink fieldCode="AU" term="%22Ameta+R%22">Ameta R</searchLink>; Department of Chemistry, PAHER University, Udaipur, Rajasthan, India. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228309336%22">Journal of pharmaceutical and biomedical analysis</searchLink> [J Pharm Biomed Anal] 2019 Sep 10; Vol. 174, pp. 396-405. <i>Date of Electronic Publication: </i>2019 Jun 05. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8309336 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-264X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2207317085%22">07317085 </searchLink><i>NLM ISO Abbreviation: </i>J Pharm Biomed Anal <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=31212140 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.jpba.2019.06.007 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 396 Titles: – TitleFull: Development and validation of a chiral LC-ESI-MS/MS method for simultaneous determination of the enantiomeric metabolites isosorbide 2-mononitrate and isosorbide 5-mononitrate of isosorbide dinitrate in rat and human plasma. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Patel BD – PersonEntity: Name: NameFull: Pulakundam N – PersonEntity: Name: NameFull: Gadekar AR – PersonEntity: Name: NameFull: Raje AA – PersonEntity: Name: NameFull: Ramanathan V – PersonEntity: Name: NameFull: Ameta R IsPartOfRelationships: – BibEntity: Dates: – D: 10 M: 09 Text: 2019 Sep 10 Type: published Y: 2019 Identifiers: – Type: issn-electronic Value: 1873-264X Numbering: – Type: volume Value: 174 Titles: – TitleFull: Journal of pharmaceutical and biomedical analysis Type: main |
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