Overcoming resistance to anabolic SARM therapy in experimental cancer cachexia with an HDAC inhibitor.

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Title: Overcoming resistance to anabolic SARM therapy in experimental cancer cachexia with an HDAC inhibitor.
Authors: Liva SG; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA., Tseng YC; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA., Dauki AM; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA., Sovic MG; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA., Vu T; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA., Henderson SE; Department of Veterinary Biosciences, College of Veterinary Medicine, Ohio State University, Columbus, OH, USA., Kuo YC; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA., Benedict JA; Center for Biostatistics, Department of Biomedical Informatics, The Ohio State University, Columbus, OH, USA., Zhang X; Center for Biostatistics, Department of Biomedical Informatics, The Ohio State University, Columbus, OH, USA., Remaily BC; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA., Kulp SK; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA., Campbell M; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA.; The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Bekaii-Saab T; Mayo Clinic Cancer Center, Phoenix, AZ, USA., Phelps MA; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA.; The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Chen CS; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan., Coss CC; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA.; The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Source: EMBO molecular medicine [EMBO Mol Med] 2020 Feb 07; Vol. 12 (2), pp. e9910. Date of Electronic Publication: 2020 Jan 13.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1757-4684
DOI:10.15252/emmm.201809910