Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout.

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Title: Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout.
Authors: Klück V; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., van Deuren RC; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Cavalli G; Internal Medicine and Clinical Immunology, Vita-Salute San Raffaele University, Milan, Italy.; Department of Medicine, University of Colorado Denver, Denver, Colorado, USA., Shaukat A; Department of Biochemistry, University of Otago, Dunedin, New Zealand., Arts P; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia., Cleophas MC; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Crișan TO; Department of Medical Genetics, Universitatea de Medicina si Farmacie Iuliu Hatieganu, Cluj-Napoca, Romania., Tausche AK; Department of Internal Medicine, Section of Rheumatology, University Clinic Carl Gustav Carus, Dresden, Saxonia, Germany., Riches P; Rheumatology and Bone Disease, University of Edinburgh, Edinburgh, UK., Dalbeth N; Department of Medicine, University of Auckland, Auckland, New Zealand., Stamp LK; Department of Medicine, Otago University, Christchurch, Canterbury, New Zealand., Hindmarsh JH; Te Rangawairua o Paratene Ngata Research Centre, Ngāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti, New Zealand., Jansen TLTA; Department of Rheumatology, VieCuri Medical Center, Venlo, The Netherlands., Janssen M; Department of Rheumatology, VieCuri Medical Center, Venlo, The Netherlands., Steehouwer M; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Lelieveld S; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., van de Vorst M; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Gilissen C; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Dagna L; Internal Medicine and Clinical Immunology, Vita-Salute San Raffaele University, Milan, Italy., Van de Veerdonk FL; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Eisenmesser EZ; Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Denver, Colorado, USA., Kim S; Laboratory of Cytokine Immunology, Konkuk University, Seoul, Korea (the Republic of)., Merriman TR; Department of Biochemistry, University of Otago, Dunedin, New Zealand., Hoischen A; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Netea MG; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Genomics and Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany., Dinarello CA; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Medicine, University of Colorado Denver, Denver, Colorado, USA., Joosten LA; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Leo.Joosten@radboudumc.nl.; Department of Medical Genetics, Universitatea de Medicina si Farmacie Iuliu Hatieganu, Cluj-Napoca, Romania.
Source: Annals of the rheumatic diseases [Ann Rheum Dis] 2020 Apr; Vol. 79 (4), pp. 536-544. Date of Electronic Publication: 2020 Feb 29.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2060 (Electronic) Linking ISSN: 00034967 NLM ISO Abbreviation: Ann Rheum Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1468-2060
DOI:10.1136/annrheumdis-2019-216233