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Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout.

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Title: Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout.
Authors: Klück V; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., van Deuren RC; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Cavalli G; Internal Medicine and Clinical Immunology, Vita-Salute San Raffaele University, Milan, Italy.; Department of Medicine, University of Colorado Denver, Denver, Colorado, USA., Shaukat A; Department of Biochemistry, University of Otago, Dunedin, New Zealand., Arts P; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia., Cleophas MC; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Crișan TO; Department of Medical Genetics, Universitatea de Medicina si Farmacie Iuliu Hatieganu, Cluj-Napoca, Romania., Tausche AK; Department of Internal Medicine, Section of Rheumatology, University Clinic Carl Gustav Carus, Dresden, Saxonia, Germany., Riches P; Rheumatology and Bone Disease, University of Edinburgh, Edinburgh, UK., Dalbeth N; Department of Medicine, University of Auckland, Auckland, New Zealand., Stamp LK; Department of Medicine, Otago University, Christchurch, Canterbury, New Zealand., Hindmarsh JH; Te Rangawairua o Paratene Ngata Research Centre, Ngāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti, New Zealand., Jansen TLTA; Department of Rheumatology, VieCuri Medical Center, Venlo, The Netherlands., Janssen M; Department of Rheumatology, VieCuri Medical Center, Venlo, The Netherlands., Steehouwer M; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Lelieveld S; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., van de Vorst M; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Gilissen C; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Dagna L; Internal Medicine and Clinical Immunology, Vita-Salute San Raffaele University, Milan, Italy., Van de Veerdonk FL; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Eisenmesser EZ; Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Denver, Colorado, USA., Kim S; Laboratory of Cytokine Immunology, Konkuk University, Seoul, Korea (the Republic of)., Merriman TR; Department of Biochemistry, University of Otago, Dunedin, New Zealand., Hoischen A; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Netea MG; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Genomics and Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany., Dinarello CA; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Medicine, University of Colorado Denver, Denver, Colorado, USA., Joosten LA; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Leo.Joosten@radboudumc.nl.; Department of Medical Genetics, Universitatea de Medicina si Farmacie Iuliu Hatieganu, Cluj-Napoca, Romania.
Source: Annals of the rheumatic diseases [Ann Rheum Dis] 2020 Apr; Vol. 79 (4), pp. 536-544. Date of Electronic Publication: 2020 Feb 29.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2060 (Electronic) Linking ISSN: 00034967 NLM ISO Abbreviation: Ann Rheum Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout.
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  Data: <searchLink fieldCode="AU" term="%22Klück+V%22">Klück V</searchLink>; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Deuren+RC%22">van Deuren RC</searchLink>; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Cavalli+G%22">Cavalli G</searchLink>; Internal Medicine and Clinical Immunology, Vita-Salute San Raffaele University, Milan, Italy.; Department of Medicine, University of Colorado Denver, Denver, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Shaukat+A%22">Shaukat A</searchLink>; Department of Biochemistry, University of Otago, Dunedin, New Zealand.<br /><searchLink fieldCode="AU" term="%22Arts+P%22">Arts P</searchLink>; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Cleophas+MC%22">Cleophas MC</searchLink>; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Crișan+TO%22">Crișan TO</searchLink>; Department of Medical Genetics, Universitatea de Medicina si Farmacie Iuliu Hatieganu, Cluj-Napoca, Romania.<br /><searchLink fieldCode="AU" term="%22Tausche+AK%22">Tausche AK</searchLink>; Department of Internal Medicine, Section of Rheumatology, University Clinic Carl Gustav Carus, Dresden, Saxonia, Germany.<br /><searchLink fieldCode="AU" term="%22Riches+P%22">Riches P</searchLink>; Rheumatology and Bone Disease, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Dalbeth+N%22">Dalbeth N</searchLink>; Department of Medicine, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Stamp+LK%22">Stamp LK</searchLink>; Department of Medicine, Otago University, Christchurch, Canterbury, New Zealand.<br /><searchLink fieldCode="AU" term="%22Hindmarsh+JH%22">Hindmarsh JH</searchLink>; Te Rangawairua o Paratene Ngata Research Centre, Ngāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti, New Zealand.<br /><searchLink fieldCode="AU" term="%22Jansen+TLTA%22">Jansen TLTA</searchLink>; Department of Rheumatology, VieCuri Medical Center, Venlo, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Janssen+M%22">Janssen M</searchLink>; Department of Rheumatology, VieCuri Medical Center, Venlo, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Steehouwer+M%22">Steehouwer M</searchLink>; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Lelieveld+S%22">Lelieveld S</searchLink>; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+de+Vorst+M%22">van de Vorst M</searchLink>; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Gilissen+C%22">Gilissen C</searchLink>; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Dagna+L%22">Dagna L</searchLink>; Internal Medicine and Clinical Immunology, Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Van+de+Veerdonk+FL%22">Van de Veerdonk FL</searchLink>; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Eisenmesser+EZ%22">Eisenmesser EZ</searchLink>; Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Denver, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; Laboratory of Cytokine Immunology, Konkuk University, Seoul, Korea (the Republic of).<br /><searchLink fieldCode="AU" term="%22Merriman+TR%22">Merriman TR</searchLink>; Department of Biochemistry, University of Otago, Dunedin, New Zealand.<br /><searchLink fieldCode="AU" term="%22Hoischen+A%22">Hoischen A</searchLink>; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Netea+MG%22">Netea MG</searchLink>; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Genomics and Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Dinarello+CA%22">Dinarello CA</searchLink>; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Medicine, University of Colorado Denver, Denver, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Joosten+LA%22">Joosten LA</searchLink>; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Leo.Joosten@radboudumc.nl.; Department of Medical Genetics, Universitatea de Medicina si Farmacie Iuliu Hatieganu, Cluj-Napoca, Romania.
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  Data: <searchLink fieldCode="JN" term="%220372355%22">Annals of the rheumatic diseases</searchLink> [Ann Rheum Dis] 2020 Apr; Vol. 79 (4), pp. 536-544. <i>Date of Electronic Publication: </i>2020 Feb 29.
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