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Bosutinib prevents vascular leakage by reducing focal adhesion turnover and reinforcing junctional integrity.

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Title: Bosutinib prevents vascular leakage by reducing focal adhesion turnover and reinforcing junctional integrity.
Authors: Botros L; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Pulmonology, Amsterdam Cardiovascular Sciences, 1081 BT Amsterdam, The Netherlands.; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Physiology, Amsterdam Cardiovascular Sciences, 1081 BT Amsterdam, The Netherlands., Pronk MCA; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Physiology, Amsterdam Cardiovascular Sciences, 1081 BT Amsterdam, The Netherlands., Juschten J; Amsterdam UMC, University of Amsterdam, Department of Intensive Care, 1105 AZ Amsterdam, The Netherlands., Liddle J; GlaxoSmithKline, Stevenage, Hertfordshire, SG1 2NY, UK., Morsing SKH; Molecular Cell Biology Lab at Dept. Molecular Cellular Haemostasis, Sanquin Research and Landsteiner Laboratory, Amsterdam, The Netherlands., van Buul JD; Molecular Cell Biology Lab at Dept. Molecular Cellular Haemostasis, Sanquin Research and Landsteiner Laboratory, Amsterdam, The Netherlands., Bates RH; GlaxoSmithKline, Stevenage, Hertfordshire, SG1 2NY, UK., Tuinman PR; Amsterdam UMC, University of Amsterdam, Department of Intensive Care, 1105 AZ Amsterdam, The Netherlands., van Bezu JSM; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Physiology, Amsterdam Cardiovascular Sciences, 1081 BT Amsterdam, The Netherlands., Huveneers S; Amsterdam UMC, University of Amsterdam, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, 1105 AZ Amsterdam, The Netherlands., Bogaard HJ; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Pulmonology, Amsterdam Cardiovascular Sciences, 1081 BT Amsterdam, The Netherlands., van Hinsbergh VWM; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Physiology, Amsterdam Cardiovascular Sciences, 1081 BT Amsterdam, The Netherlands., Hordijk PL; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Physiology, Amsterdam Cardiovascular Sciences, 1081 BT Amsterdam, The Netherlands., Aman J; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Pulmonology, Amsterdam Cardiovascular Sciences, 1081 BT Amsterdam, The Netherlands j.aman@amsterdamumc.nl.
Source: Journal of cell science [J Cell Sci] 2020 May 14; Vol. 133 (9). Date of Electronic Publication: 2020 May 14.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Company of Biologists Country of Publication: England NLM ID: 0052457 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-9137 (Electronic) Linking ISSN: 00219533 NLM ISO Abbreviation: J Cell Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1477-9137
DOI:10.1242/jcs.240077