Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo.

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Title: Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo.
Authors: Desaphy JF; Department of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari Aldo Moro, Bari, Italy. Electronic address: jeanfrancois.desaphy@uniba.it., Farinato A; Department of Pharmacy & Drug Sciences, University of Bari Aldo Moro, Bari, Italy., Altamura C; Department of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari Aldo Moro, Bari, Italy., De Bellis M; Department of Pharmacy & Drug Sciences, University of Bari Aldo Moro, Bari, Italy., Imbrici P; Department of Pharmacy & Drug Sciences, University of Bari Aldo Moro, Bari, Italy., Tarantino N; Department of Pharmacy & Drug Sciences, University of Bari Aldo Moro, Bari, Italy., Caccia C; Open R&D Department, Zambon S.p.A., Bresso, MI, Italy., Melloni E; Open R&D Department, Zambon S.p.A., Bresso, MI, Italy., Padoani G; Open R&D Department, Zambon S.p.A., Bresso, MI, Italy., Vailati S; Open R&D Department, Zambon S.p.A., Bresso, MI, Italy., Keywood C; Open R&D Department, Zambon S.p.A., Bresso, MI, Italy., Carratù MR; Department of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari Aldo Moro, Bari, Italy., De Luca A; Department of Pharmacy & Drug Sciences, University of Bari Aldo Moro, Bari, Italy., Conte D; Department of Pharmacy & Drug Sciences, University of Bari Aldo Moro, Bari, Italy., Pierno S; Department of Pharmacy & Drug Sciences, University of Bari Aldo Moro, Bari, Italy.
Source: Experimental neurology [Exp Neurol] 2020 Jun; Vol. 328, pp. 113287. Date of Electronic Publication: 2020 Mar 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1090-2430
DOI:10.1016/j.expneurol.2020.113287