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Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo.

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Title: Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo.
Authors: Desaphy JF; Department of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari Aldo Moro, Bari, Italy. Electronic address: jeanfrancois.desaphy@uniba.it., Farinato A; Department of Pharmacy & Drug Sciences, University of Bari Aldo Moro, Bari, Italy., Altamura C; Department of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari Aldo Moro, Bari, Italy., De Bellis M; Department of Pharmacy & Drug Sciences, University of Bari Aldo Moro, Bari, Italy., Imbrici P; Department of Pharmacy & Drug Sciences, University of Bari Aldo Moro, Bari, Italy., Tarantino N; Department of Pharmacy & Drug Sciences, University of Bari Aldo Moro, Bari, Italy., Caccia C; Open R&D Department, Zambon S.p.A., Bresso, MI, Italy., Melloni E; Open R&D Department, Zambon S.p.A., Bresso, MI, Italy., Padoani G; Open R&D Department, Zambon S.p.A., Bresso, MI, Italy., Vailati S; Open R&D Department, Zambon S.p.A., Bresso, MI, Italy., Keywood C; Open R&D Department, Zambon S.p.A., Bresso, MI, Italy., Carratù MR; Department of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari Aldo Moro, Bari, Italy., De Luca A; Department of Pharmacy & Drug Sciences, University of Bari Aldo Moro, Bari, Italy., Conte D; Department of Pharmacy & Drug Sciences, University of Bari Aldo Moro, Bari, Italy., Pierno S; Department of Pharmacy & Drug Sciences, University of Bari Aldo Moro, Bari, Italy.
Source: Experimental neurology [Exp Neurol] 2020 Jun; Vol. 328, pp. 113287. Date of Electronic Publication: 2020 Mar 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo.
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  Data: <searchLink fieldCode="AU" term="%22Desaphy+JF%22">Desaphy JF</searchLink>; Department of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari Aldo Moro, Bari, Italy. Electronic address: jeanfrancois.desaphy@uniba.it.<br /><searchLink fieldCode="AU" term="%22Farinato+A%22">Farinato A</searchLink>; Department of Pharmacy & Drug Sciences, University of Bari Aldo Moro, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Altamura+C%22">Altamura C</searchLink>; Department of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari Aldo Moro, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22De+Bellis+M%22">De Bellis M</searchLink>; Department of Pharmacy & Drug Sciences, University of Bari Aldo Moro, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Imbrici+P%22">Imbrici P</searchLink>; Department of Pharmacy & Drug Sciences, University of Bari Aldo Moro, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Tarantino+N%22">Tarantino N</searchLink>; Department of Pharmacy & Drug Sciences, University of Bari Aldo Moro, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Caccia+C%22">Caccia C</searchLink>; Open R&D Department, Zambon S.p.A., Bresso, MI, Italy.<br /><searchLink fieldCode="AU" term="%22Melloni+E%22">Melloni E</searchLink>; Open R&D Department, Zambon S.p.A., Bresso, MI, Italy.<br /><searchLink fieldCode="AU" term="%22Padoani+G%22">Padoani G</searchLink>; Open R&D Department, Zambon S.p.A., Bresso, MI, Italy.<br /><searchLink fieldCode="AU" term="%22Vailati+S%22">Vailati S</searchLink>; Open R&D Department, Zambon S.p.A., Bresso, MI, Italy.<br /><searchLink fieldCode="AU" term="%22Keywood+C%22">Keywood C</searchLink>; Open R&D Department, Zambon S.p.A., Bresso, MI, Italy.<br /><searchLink fieldCode="AU" term="%22Carratù+MR%22">Carratù MR</searchLink>; Department of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari Aldo Moro, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22De+Luca+A%22">De Luca A</searchLink>; Department of Pharmacy & Drug Sciences, University of Bari Aldo Moro, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Conte+D%22">Conte D</searchLink>; Department of Pharmacy & Drug Sciences, University of Bari Aldo Moro, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Pierno+S%22">Pierno S</searchLink>; Department of Pharmacy & Drug Sciences, University of Bari Aldo Moro, Bari, Italy.
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