Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition.
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| Title: | Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition. |
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| Authors: | Mondal G; Department of Pathology, University of California, San Francisco, CA, USA., Lee JC; Department of Pathology, University of California, San Francisco, CA, USA., Ravindranathan A; Department of Pathology, University of California, San Francisco, CA, USA., Villanueva-Meyer JE; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA., Tran QT; Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA., Allen SJ; Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA., Barreto J; Department of Pathology, University of California, San Francisco, CA, USA., Gupta R; Department of Pathology, University of California, San Francisco, CA, USA., Doo P; Institute for Human Genetics, University of California, San Francisco, CA, USA., Van Ziffle J; Department of Pathology, University of California, San Francisco, CA, USA.; Clinical Cancer Genomics Laboratory, University of California, San Francisco, CA, USA., Onodera C; Department of Pathology, University of California, San Francisco, CA, USA.; Clinical Cancer Genomics Laboratory, University of California, San Francisco, CA, USA., Devine P; Department of Pathology, University of California, San Francisco, CA, USA.; Clinical Cancer Genomics Laboratory, University of California, San Francisco, CA, USA., Grenert JP; Department of Pathology, University of California, San Francisco, CA, USA.; Clinical Cancer Genomics Laboratory, University of California, San Francisco, CA, USA., Samuel D; Department of Hematology/Oncology, Valley Children's Hospital, Madera, CA, USA., Li R; Department of Pathology, Children's of Alabama, Birmingham, AL, USA., Metrock LK; Department of Pediatric Hematology/Oncology, University of Alabama, Birmingham, AL, USA., Jin LW; Department of Pathology, University of California Davis Medical Center, Sacramento, CA, USA., Antony R; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of California Davis Medical Center, Sacramento, CA, USA., Alashari M; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA., Cheshier S; Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, UT, USA., Whipple NS; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA., Bruggers C; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA., Raffel C; Department of Neurological Surgery, University of California, San Francisco, CA, USA., Gupta N; Department of Neurological Surgery, University of California, San Francisco, CA, USA., Kline CN; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of California, San Francisco, CA, USA.; Department of Neurology, University of California, San Francisco, CA, USA., Reddy A; Department of Neurology, University of California, San Francisco, CA, USA., Banerjee A; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of California, San Francisco, CA, USA., Hall MD; Department of Radiation Oncology, Miami Cancer Institute, Miami, FL, USA., Mehta MP; Department of Radiation Oncology, Miami Cancer Institute, Miami, FL, USA., Khatib Z; Division of Hematology/Oncology, Department of Pediatrics, Nicklaus Children's Hospital, Miami, FL, USA., Maher OM; Division of Hematology/Oncology, Department of Pediatrics, Nicklaus Children's Hospital, Miami, FL, USA., Brathwaite C; Department of Pathology, Nicklaus Children's Hospital, Miami, FL, USA., Pekmezci M; Department of Pathology, University of California, San Francisco, CA, USA., Phillips JJ; Department of Pathology, University of California, San Francisco, CA, USA.; Department of Neurological Surgery, University of California, San Francisco, CA, USA., Bollen AW; Department of Pathology, University of California, San Francisco, CA, USA., Tihan T; Department of Pathology, University of California, San Francisco, CA, USA., Lucas JT Jr; Department of Radiation Oncology, St Jude Children's Research Hospital, Memphis, TN, USA., Broniscer A; Division of Pediatric Hematology/Oncology, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Berger MS; Department of Neurological Surgery, University of California, San Francisco, CA, USA., Perry A; Department of Pathology, University of California, San Francisco, CA, USA.; Department of Neurological Surgery, University of California, San Francisco, CA, USA., Orr BA; Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA., Solomon DA; Department of Pathology, University of California, San Francisco, CA, USA. david.solomon@ucsf.edu.; Clinical Cancer Genomics Laboratory, University of California, San Francisco, CA, USA. david.solomon@ucsf.edu. |
| Source: | Acta neuropathologica [Acta Neuropathol] 2020 Jun; Vol. 139 (6), pp. 1071-1088. Date of Electronic Publication: 2020 Apr 17. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1432-0533 |
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| DOI: | 10.1007/s00401-020-02155-5 |
