View in EDS HTML Full Text PDF Full Text

Treatment of patients with nonsevere and severe coronavirus disease 2019: an evidence-based guideline.

Saved in:
Bibliographic Details
Title: Treatment of patients with nonsevere and severe coronavirus disease 2019: an evidence-based guideline.
Authors: Ye Z; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Rochwerg B; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Wang Y; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Adhikari NK; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Murthy S; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Lamontagne F; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Fowler RA; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Qiu H; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Wei L; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Sang L; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Loeb M; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Shen N; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Huang M; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Jiang Z; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Arabi YM; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Colunga-Lozano LE; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Jiang L; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Koh Y; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Liu D; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Liu F; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Phua J; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Shen A; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Huo T; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Du B; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing dubin98@gmail.com zhaisuodi@163.com guyatt@mcmaster.ca., Zhai S; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing., Guyatt GH; Department of Health Research Methods, Evidence and Impact Canada (Ye, Rochwerg, Guyatt, Colunga-Lozano) and of Medicine (Rochwerg), McMaster University, Hamilton, Ont.; Department of Pharmacy (Wang), Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Medicine, Interdepartmental Division of Critical Care Medicine (Adhikari, Fowler), University of Toronto, Toronto, Ont.; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari, Fowler), Sunnybrook Health Sciences Centre, Toronto, Ont.; Department of Pediatrics (Murthy), University of British Columbia, Vancouver, BC; Department of Medicine (Lamontagne), Université de Sherbrooke; Centre de recherche du CHUS de Sherbrooke (Lamontagne), Sherbrooke, Que.; Department of Critical Care Medicine (Qiu), Zhongda hospital, School of Medicine, Southeast University, Nanjing, China; Department of Pharmacy (Wei), the First Affiliated Hospital of Guangzhou University of Medical; Department of Critical Care Medicine (Sang), the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou, China; Department of Pathology and Molecular Medicine and Health Research Methods, Evidence, and Impact (Loeb), McMaster University, Hamilton, Ont.; Department of Respiratory and Critical Care Medicine (Shen), Peking University Third Hospital, Beijing, China; Guangdong kuaiwen information technology co. LTD (Huang), Guanzhong, China; Kunshan Guanghui Precise Metal Co. Ltd. (Jiang), Kunshan, China; Intensive Care Department (Arabi), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia; Department of Clinical Medicine (Colunga-Lozano), Health Science Center, Universidad de Guadalajara, Guadalajara, Mexico; Department of Critical Care Medicine (Jiang), Xuanwu Hospital, Capital Medical School, Beijing, China; Department of Pulmonary and Critical Care Medicine (Koh), University of Ulsan College of Medicine, Seoul, South Korea; Department of Pharmacy (Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Pharmacy (Liu, Zhai), Peking University Third Hospital, Beijing, China; Fast and Chronic Programmes (Phua), Alexandra Hospital, National University Health System, Singapore; Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (Shen), Anhui, China; General Surgery Department (Huo), Peking University Third Hospital, Beijing, China; Medical Intensive Care Unit (Du), Peking Union Medical College Hospital, Beijing.
Source: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne [CMAJ] 2020 May 19; Vol. 192 (20), pp. E536-E545. Date of Electronic Publication: 2020 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: Canadian Medical Association Country of Publication: Canada NLM ID: 9711805 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1488-2329 (Electronic) Linking ISSN: 08203946 NLM ISO Abbreviation: CMAJ Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
Description
ISSN:1488-2329
DOI:10.1503/cmaj.200648