Autologous haematopoietic stem-cell transplantation versus bortezomib-melphalan-prednisone, with or without bortezomib-lenalidomide-dexamethasone consolidation therapy, and lenalidomide maintenance for newly diagnosed multiple myeloma (EMN02/HO95): a multicentre, randomised, open-label, phase 3 study.

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Title: Autologous haematopoietic stem-cell transplantation versus bortezomib-melphalan-prednisone, with or without bortezomib-lenalidomide-dexamethasone consolidation therapy, and lenalidomide maintenance for newly diagnosed multiple myeloma (EMN02/HO95): a multicentre, randomised, open-label, phase 3 study.
Authors: Cavo M; Seràgnoli Institute of Hematology, Department of Experimental, Diagnostic and Specialty Medicine, Bologna University School of Medicine, S Orsola Malpighi Hospital, Bologna, Italy. Electronic address: michele.cavo@unibo.it., Gay F; Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy., Beksac M; Department of Hematology, Ankara University School of Medicine, Ankara, Turkey., Pantani L; Seràgnoli Institute of Hematology, Department of Experimental, Diagnostic and Specialty Medicine, Bologna University School of Medicine, S Orsola Malpighi Hospital, Bologna, Italy., Petrucci MT; Hematology, Department of Translational and Precision Medicine, Azienda Ospedaliera Policlinico Umberto I, Sapienza University of Rome, Rome, Italy., Dimopoulos MA; Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Dozza L; Seràgnoli Institute of Hematology, Department of Experimental, Diagnostic and Specialty Medicine, Bologna University School of Medicine, S Orsola Malpighi Hospital, Bologna, Italy., van der Holt B; Department of Trials and Statistics-HOVON Data Centre, Erasmus MC Cancer Institute, Rotterdam, Netherlands., Zweegman S; Department of Hematology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, Netherlands., Oliva S; Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy., van der Velden VHJ; Department of Immunology, Erasmus MC, Rotterdam, Netherlands., Zamagni E; Seràgnoli Institute of Hematology, Department of Experimental, Diagnostic and Specialty Medicine, Bologna University School of Medicine, S Orsola Malpighi Hospital, Bologna, Italy., Palumbo GA; Dipartimento di Science Mediche Chirurgiche e Tecnologie Avanzate 'GF Ingrassia', Università degli Studi di Catania, Catania, Italy., Patriarca F; Clinical Hematology and Bone Marrow Transplant Centre, S Maria della Misericordia University Hospital, DAME, University of Udine, Udine, Italy., Montefusco V; Hematology Department, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy., Galli M; Hematology and Bone Marrow Transplant Unit, ASST-Papa Giovanni XXIII, Bergamo, Italy., Maisnar V; 4th Department of Internal Medicine-Hematology, Charles University Hospital and Faculty of Medicine, Hradec Kralove, Czech Republic., Gamberi B; Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Hansson M; Skane University Hospital, Lund, Sweden., Belotti A; SC Ematologia e Dipartimento di Oncologia Clinica, AO Spedali Civili, Brescia, Italy., Pour L; University Hospital Brno, Brno, Czech Republic., Ypma P; Department of Hematology, Haga Hospital, The Hague, Netherlands., Grasso M; SC Ematologia, Azienda Ospedaliera S Croce-Carle, Cuneo, Italy., Croockewit A; Department of Hematology, Radboud University Medical Centre, Nijmegen, Netherlands., Ballanti S; Reparto di Ematologia con TMO, Ospedale Santa Maria della Misericordia, Perugia, Italy., Offidani M; Clinica di Ematologia, AOU Ospedali Riuniti di Ancona, Ancona, Italy., Vincelli ID; Division of Haematology, Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli, Reggio Calabria, Italy., Zambello R; Hematology, Azienda Ospedaliera di Padova, Padua, Italy., Liberati AM; Faculty of Medicine, Università degli Studi di Perugia, Perugia, Italy., Andersen NF; Department of Haematology, Aarhus University Hospital, Aarhus, Denmark., Broijl A; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands., Troia R; Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy., Pascarella A; Hematology Unit, Ospedale dell'Angelo, Mestre, Venice, Italy., Benevolo G; Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy., Levin MD; Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands., Bos G; Department of Haematology, Maastricht University Medical Center, Maastricht, Netherlands., Ludwig H; Wilhelminen Cancer Research Institute, Wilhelminenspital, Vienna, Austria., Aquino S; Ematologia e Centro Trapianti, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Morelli AM; Clinical Hematology, Department of Hematology, Transfusion Medicine and Biotechnology, 'Spirito Santo' Civic Hospital, Pescara, Italy., Wu KL; Department of Hematology, ZNA Stuivenberg, Antwerp, Belgium., Boersma R; Department of Internal Medicine, Amphia Hospital Breda, Breda, Netherlands., Hajek R; Department of Hematooncology, University Hospital Ostrava and University of Ostrava, Ostrava, Czech Republic., Durian M; University Hospital and Faculty of Medicine, Hradec Kralove, Czech Republic., von dem Borne PA; Department of Hematology, Leiden University Medical Center, Leiden, Netherlands., Caravita di Toritto T; UOSD Ematologia ASL Roma 1, Rome, Italy., Zander T; Department Oncology/Hematology, Kantonsspital, Lucerne, Switzerland., Driessen C; Department Oncology/Hematology, Kantonsspital, St Gallen, Switzerland., Specchia G; Hematology, University Aldo Moro, Bari, Italy., Waage A; Department of Hematology, St Olavs Hospital and Norwegian University of Science and Technology, Trondheim, Norway., Gimsing P; Department of Haematology, University of Copenhagen, Copenhagen, Denmark., Mellqvist UH; Department of Medicine, Section of Hematology and Coagulation, South Elvsborg Hospital, Gothenburg, Sweden., van Marwijk Kooy M; Isala Kliniek, Zwolle, Netherlands., Minnema M; Department of Hematology, UMC Utrecht, University Utrecht, Utrecht, Netherlands., Mandigers C; Department of Hematology, Canisius-Wilhelmina Hospital, Nijmegen, Netherlands., Cafro AM; Department of Hematology, ASST Grande Ospedale Metropolitano, Niguarda, Milan, Italy., Palmas A; Haematology, Ospedale San Francesco, Nuoro, Italy., Carvalho S; Instituto Português de Oncologia de Lisboa Francisco Gentil, IPOLFG, Lisbon, Portugal., Spencer A; Department of Haematology, Alfred Hospital-Monash University, Melbourne, VIC, Australia., Boccadoro M; Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy., Sonneveld P; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands.
Source: The Lancet. Haematology [Lancet Haematol] 2020 Jun; Vol. 7 (6), pp. e456-e468. Date of Electronic Publication: 2020 Apr 30.
Publication Type: Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101643584 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3026 (Electronic) Linking ISSN: 23523026 NLM ISO Abbreviation: Lancet Haematol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2352-3026
DOI:10.1016/S2352-3026(20)30099-5