Engineered IL-21 Cytokine Muteins Fused to Anti-PD-1 Antibodies Can Improve CD8+ T Cell Function and Anti-tumor Immunity.
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| Title: | Engineered IL-21 Cytokine Muteins Fused to Anti-PD-1 Antibodies Can Improve CD8+ T Cell Function and Anti-tumor Immunity. |
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| Authors: | Shen S; Departments of Oncology Research, Amgen Research, South San Francisco, CA, United States., Sckisel G; Departments of Oncology Research, Amgen Research, South San Francisco, CA, United States., Sahoo A; Departments of Oncology Research, Amgen Research, South San Francisco, CA, United States., Lalani A; Departments of Oncology Research, Amgen Research, South San Francisco, CA, United States., Otter DD; Departments of Oncology Research, Amgen Research, South San Francisco, CA, United States., Pearson J; Pharmacokinetics and Drug Metabolism, Amgen Research, South San Francisco, CA, United States., DeVoss J; Departments of Oncology Research, Amgen Research, South San Francisco, CA, United States., Cheng J; Departments of Oncology Research, Amgen Research, South San Francisco, CA, United States., Casey SC; Departments of Oncology Research, Amgen Research, South San Francisco, CA, United States., Case R; Discovery Attribute Sciences, Amgen Research, South San Francisco, CA, United States., Yang M; Biologics Discovery, Amgen Research, Thousand Oaks, CA, United States., Low R; Biologics Discovery, Amgen Research, Thousand Oaks, CA, United States., Daris M; Biologics Discovery, Amgen Research, Thousand Oaks, CA, United States., Fan B; Biologics Discovery, Amgen Research, Thousand Oaks, CA, United States., Agrawal NJ; Biologics Discovery, Amgen Research, Thousand Oaks, CA, United States., Ali K; Departments of Oncology Research, Amgen Research, South San Francisco, CA, United States. |
| Source: | Frontiers in immunology [Front Immunol] 2020 May 08; Vol. 11, pp. 832. Date of Electronic Publication: 2020 May 08 (Print Publication: 2020). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2020.00832 |
