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Engineered IL-21 Cytokine Muteins Fused to Anti-PD-1 Antibodies Can Improve CD8+ T Cell Function and Anti-tumor Immunity.

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Title: Engineered IL-21 Cytokine Muteins Fused to Anti-PD-1 Antibodies Can Improve CD8+ T Cell Function and Anti-tumor Immunity.
Authors: Shen S; Departments of Oncology Research, Amgen Research, South San Francisco, CA, United States., Sckisel G; Departments of Oncology Research, Amgen Research, South San Francisco, CA, United States., Sahoo A; Departments of Oncology Research, Amgen Research, South San Francisco, CA, United States., Lalani A; Departments of Oncology Research, Amgen Research, South San Francisco, CA, United States., Otter DD; Departments of Oncology Research, Amgen Research, South San Francisco, CA, United States., Pearson J; Pharmacokinetics and Drug Metabolism, Amgen Research, South San Francisco, CA, United States., DeVoss J; Departments of Oncology Research, Amgen Research, South San Francisco, CA, United States., Cheng J; Departments of Oncology Research, Amgen Research, South San Francisco, CA, United States., Casey SC; Departments of Oncology Research, Amgen Research, South San Francisco, CA, United States., Case R; Discovery Attribute Sciences, Amgen Research, South San Francisco, CA, United States., Yang M; Biologics Discovery, Amgen Research, Thousand Oaks, CA, United States., Low R; Biologics Discovery, Amgen Research, Thousand Oaks, CA, United States., Daris M; Biologics Discovery, Amgen Research, Thousand Oaks, CA, United States., Fan B; Biologics Discovery, Amgen Research, Thousand Oaks, CA, United States., Agrawal NJ; Biologics Discovery, Amgen Research, Thousand Oaks, CA, United States., Ali K; Departments of Oncology Research, Amgen Research, South San Francisco, CA, United States.
Source: Frontiers in immunology [Front Immunol] 2020 May 08; Vol. 11, pp. 832. Date of Electronic Publication: 2020 May 08 (Print Publication: 2020).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Engineered IL-21 Cytokine Muteins Fused to Anti-PD-1 Antibodies Can Improve CD8+ T Cell Function and Anti-tumor Immunity.
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