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Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2C Receptor-Positive Allosteric Modulators with Enhanced Drug-like Properties.

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Bibliographic Details
Title: Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2C Receptor-Positive Allosteric Modulators with Enhanced Drug-like Properties.
Authors: Wold EA; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.; Chemical Biology Program and the Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States., Garcia EJ; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States., Wild CT; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.; Chemical Biology Program and the Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States., Miszkiel JM; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States., Soto CA; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States., Chen J; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.; Chemical Biology Program and the Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States., Pazdrak K; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States., Fox RG; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States., Anastasio NC; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.; Chemical Biology Program and the Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States., Cunningham KA; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.; Chemical Biology Program and the Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States., Zhou J; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.; Chemical Biology Program and the Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2020 Jul 23; Vol. 63 (14), pp. 7529-7544. Date of Electronic Publication: 2020 Jul 07.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.9b01953