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Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer.

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Title: Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer.
Authors: Slavish PJ; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Chi L; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Yun MK; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Tsurkan L; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Martinez NE; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Jonchere B; Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Chai SC; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Connelly M; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Waddell MB; Molecular Interaction Analysis Shared Resource, St. Jude Children's Research Hospital, Memphis, Tennessee., Das S; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Neale G; Hartwell Center, St. Jude Children's Research Hospital, Memphis, Tennessee., Li Z; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Shadrick WR; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Olsen RR; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Freeman KW; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Low JA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Price JE; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Young BM; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Bharatham N; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Boyd VA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Yang J; Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee., Lee RE; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Morfouace M; Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Roussel MF; Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Chen T; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Savic D; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee., Guy RK; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., White SW; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Shelat AA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee. phil.potter@stjude.org anang.shelat@stjude.org., Potter PM; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee. phil.potter@stjude.org anang.shelat@stjude.org.
Source: Cancer research [Cancer Res] 2020 Sep 01; Vol. 80 (17), pp. 3507-3518. Date of Electronic Publication: 2020 Jul 10.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
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  Data: Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Slavish+PJ%22">Slavish PJ</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Chi+L%22">Chi L</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Yun+MK%22">Yun MK</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Tsurkan+L%22">Tsurkan L</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Martinez+NE%22">Martinez NE</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Jonchere+B%22">Jonchere B</searchLink>; Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Chai+SC%22">Chai SC</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Connelly+M%22">Connelly M</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Waddell+MB%22">Waddell MB</searchLink>; Molecular Interaction Analysis Shared Resource, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Das+S%22">Das S</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Neale+G%22">Neale G</searchLink>; Hartwell Center, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Shadrick+WR%22">Shadrick WR</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Olsen+RR%22">Olsen RR</searchLink>; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Freeman+KW%22">Freeman KW</searchLink>; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Low+JA%22">Low JA</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Price+JE%22">Price JE</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Young+BM%22">Young BM</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Bharatham+N%22">Bharatham N</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Boyd+VA%22">Boyd VA</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Lee+RE%22">Lee RE</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Morfouace+M%22">Morfouace M</searchLink>; Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Roussel+MF%22">Roussel MF</searchLink>; Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Chen+T%22">Chen T</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Savic+D%22">Savic D</searchLink>; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Guy+RK%22">Guy RK</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22White+SW%22">White SW</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Shelat+AA%22">Shelat AA</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee. phil.potter@stjude.org anang.shelat@stjude.org.<br /><searchLink fieldCode="AU" term="%22Potter+PM%22">Potter PM</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee. phil.potter@stjude.org anang.shelat@stjude.org.
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  Data: <searchLink fieldCode="JN" term="%222984705R%22">Cancer research</searchLink> [Cancer Res] 2020 Sep 01; Vol. 80 (17), pp. 3507-3518. <i>Date of Electronic Publication: </i>2020 Jul 10.
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