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Mechanistic Multilayer Quantitative Model for Nonlinear Pharmacokinetics, Target Occupancy and Pharmacodynamics (PK/TO/PD) Relationship of D-Amino Acid Oxidase Inhibitor, TAK-831 in Mice.

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Title: Mechanistic Multilayer Quantitative Model for Nonlinear Pharmacokinetics, Target Occupancy and Pharmacodynamics (PK/TO/PD) Relationship of D-Amino Acid Oxidase Inhibitor, TAK-831 in Mice.
Authors: Yoneyama T; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan. tomoki.yoneyama@takeda.com., Sato S; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan., Sykes A; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Cambridge Ltd, Cambridge, UK., Fradley R; Pharmacology, Takeda Cambridge Ltd, Cambridge, UK., Stafford S; Pharmacology, Takeda Cambridge Ltd, Cambridge, UK., Bechar S; Pharmacology, Takeda Cambridge Ltd, Cambridge, UK., Howley E; Pharmacology, Takeda Cambridge Ltd, Cambridge, UK., Patel T; Pharmacology, Takeda Cambridge Ltd, Cambridge, UK., Tagawa Y; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan., Moriwaki T; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan., Asahi S; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
Source: Pharmaceutical research [Pharm Res] 2020 Aug 05; Vol. 37 (8), pp. 164. Date of Electronic Publication: 2020 Aug 05.
Publication Type: Journal Article
Journal Info: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-904X (Electronic) Linking ISSN: 07248741 NLM ISO Abbreviation: Pharm Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1573-904X
DOI:10.1007/s11095-020-02893-x