Loss of Furin in β-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to β-Cell Dysfunction.

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Title: Loss of Furin in β-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to β-Cell Dysfunction.
Authors: Brouwers B; Laboratory for Biochemical Neuroendocrinology, Department of Human Genetics, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.; Metabolic Research Laboratories, Wellcome Trust Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, U.K., Coppola I; Laboratory for Biochemical Neuroendocrinology, Department of Human Genetics, Katholieke Universiteit (KU) Leuven, Leuven, Belgium., Vints K; Electron Microscopy Platform and Vlaams Instituut voor Biotechnologie (VIB) Bioimaging Core, VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; Leuven Brain Institute, Department of Neurosciences, KU Leuven, Leuven, Belgium., Dislich B; German Center for Neurodegenerative Diseases, Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Jouvet N; Institut de recherches cliniques de Montréal, Montréal, Quebec, Canada., Van Lommel L; Gene Expression Unit, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium., Segers C; Laboratory for Biochemical Neuroendocrinology, Department of Human Genetics, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.; Interdisciplinary Biosciences Group, Belgian Nuclear Research Centre, SCK CEN, Mol, Belgium.; Department of Bioscience Engineering, University of Antwerp, Antwerp, Belgium., Gounko NV; Electron Microscopy Platform and Vlaams Instituut voor Biotechnologie (VIB) Bioimaging Core, VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; Leuven Brain Institute, Department of Neurosciences, KU Leuven, Leuven, Belgium., Thorrez L; Department of Development and Regeneration, Campus Kulak, KU Leuven, Kortrijk, Belgium., Schuit F; Gene Expression Unit, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium., Lichtenthaler SF; German Center for Neurodegenerative Diseases, Munich, Germany.; Neuroproteomics, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Estall JL; Institut de recherches cliniques de Montréal, Montréal, Quebec, Canada., Declercq J; Laboratory for Biochemical Neuroendocrinology, Department of Human Genetics, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.; German Center for Neurodegenerative Diseases, Munich, Germany., Ramos-Molina B; Laboratory for Biochemical Neuroendocrinology, Department of Human Genetics, Katholieke Universiteit (KU) Leuven, Leuven, Belgium john.creemers@kuleuven.be brunoramosmolina@gmail.com.; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain., Creemers JWM; Laboratory for Biochemical Neuroendocrinology, Department of Human Genetics, Katholieke Universiteit (KU) Leuven, Leuven, Belgium john.creemers@kuleuven.be brunoramosmolina@gmail.com.
Source: Diabetes [Diabetes] 2021 Feb; Vol. 70 (2), pp. 492-503. Date of Electronic Publication: 2020 Dec 04.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1939-327X
DOI:10.2337/db20-0474