CRISPR/Cas9-engineered Gad1 elimination in rats leads to complex behavioral changes: implications for schizophrenia.

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Title: CRISPR/Cas9-engineered Gad1 elimination in rats leads to complex behavioral changes: implications for schizophrenia.
Authors: Fujihara K; Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Maebashi City, Gunma, 371-8511, Japan. psy_fujihara@gunma-u.ac.jp.; Department of Psychiatry and Neuroscience, Gunma University Graduate School of Medicine, Maebashi City, Gunma, 371-8511, Japan. psy_fujihara@gunma-u.ac.jp., Yamada K; Institute of Psychology and Behavioral Neuroscience, University of Tsukuba, Tsukuba City, Ibaraki, 305-8577, Japan., Ichitani Y; Institute of Psychology and Behavioral Neuroscience, University of Tsukuba, Tsukuba City, Ibaraki, 305-8577, Japan., Kakizaki T; Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Maebashi City, Gunma, 371-8511, Japan., Jiang W; Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Maebashi City, Gunma, 371-8511, Japan., Miyata S; Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Maebashi City, Gunma, 371-8511, Japan., Suto T; Department of Anesthesiology, Gunma University Graduate School of Medicine, Maebashi City, Gunma, 371-8511, Japan., Kato D; Department of Anesthesiology, Gunma University Graduate School of Medicine, Maebashi City, Gunma, 371-8511, Japan., Saito S; Department of Anesthesiology, Gunma University Graduate School of Medicine, Maebashi City, Gunma, 371-8511, Japan., Watanabe M; Department of Anatomy, Faculty of Medicine, Hokkaido University, Sapporo City, Hokkaido, 060-8638, Japan., Kajita Y; Department of Physiology, Graduate School of Medicine, Tohoku University, Sendai City, Miyagi, 980-8575, Japan., Ohshiro T; Department of Physiology, Graduate School of Medicine, Tohoku University, Sendai City, Miyagi, 980-8575, Japan., Mushiake H; Department of Physiology, Graduate School of Medicine, Tohoku University, Sendai City, Miyagi, 980-8575, Japan., Miyasaka Y; Institute of Experimental Animal Sciences, Graduate School of Medicine, Osaka University, Suita City, Osaka, 565-0871, Japan., Mashimo T; Institute of Experimental Animal Sciences, Graduate School of Medicine, Osaka University, Suita City, Osaka, 565-0871, Japan.; Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, 108-8639, Japan., Yasuda H; Division of Physiology, Faculty of Medicine, Saga University, Saga City, Saga, 849-8501, Japan., Yanagawa Y; Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Maebashi City, Gunma, 371-8511, Japan. yuchio@gunma-u.ac.jp.
Source: Translational psychiatry [Transl Psychiatry] 2020 Dec 08; Vol. 10 (1), pp. 426. Date of Electronic Publication: 2020 Dec 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2158-3188
DOI:10.1038/s41398-020-01108-6