Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
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| Title: | Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. |
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| Authors: | Lagou V; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Department of Microbiology and Immunology, Laboratory of Adaptive Immunity, KU Leuven, Leuven, Belgium.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Hottenga JJ; Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, VU University medical center, Amsterdam, the Netherlands., Grallert H; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD, München-Neuherberg, Germany., Perry JRB; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Bouatia-Naji N; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; INSERM U970, Paris Cardiovascular Research Center PARCC, 75006, Paris, France., Marullo L; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Rybin D; Boston University Data Coordinating Center, Boston, MA, USA., Jansen R; Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands., Min JL; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol Medical School, University of Bristol, Bristol, United Kingdom., Dimas AS; Institute for Bioinnovation, Biomedical Sciences Research Center Al. Fleming, Vari, Greece., Ulrich A; Department of Medicine, Imperial College London, London, UK., Zudina L; Department of Medicine, Imperial College London, London, UK., Gådin JR; Cardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Karolinska University Hospital, Solna, Sweden., Jiang L; Department of Medicine, Imperial College London, London, UK.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Faggian A; Department of Medicine, Imperial College London, London, UK., Bonnefond A; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; Department of Medicine, Imperial College London, London, UK., Fadista J; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Stathopoulou MG; Université de Lorraine, IGE-PCV, F-54000, Nancy, France., Isaacs A; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; CARIM School for Cardiovascular Diseases and Maastricht Centre for Systems Biology (MaCSBio, Maastricht University, Maastricht, the Netherlands.; Department of Physiology, Maastricht University, Maastricht, the Netherlands., Willems SM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Navarro P; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Tanaka T; Translational Gerontology Branch, Longitudinal Study Section, National Institute on Aging, Baltimore, MD, USA., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Montasser ME; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA., O'Connell JR; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Webster RJ; Laboratory for Cancer Medicine, Harry Perkins Institute of Medical Research, University of Western Australia Centre for Medical Research, Nedlands, WA, Australia., Saxena R; Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Departmentartment of Anesthesia, Critical Care and Pain Medicine, MGH, Boston, MA, USA., Stafford JM; Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Pourcain BS; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol Medical School, University of Bristol, Bristol, United Kingdom., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol Medical School, University of Bristol, Bristol, United Kingdom., Salo P; Public Health Genomics Unit, Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland., Shin SY; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Amin N; Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands., Smith AV; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Li G; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Ford I; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK., Johnson PCD; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.; Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, Glasgow, UK., Johnson T; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Kapur K; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland., Thorleifsson G; deCODE Genetics, Reykjavik, Iceland., Strawbridge RJ; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.; Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK., Rasmussen-Torvik LJ; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Esko T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Mihailov E; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Fall T; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Fraser RM; Usher Institute, University of Edinburgh, Edinburgh, UK.; Synpromics Ltd, Roslin Innovation Centre, Easter Bush Campus, Edinburgh, EH25 9RG, UK., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Genentech, 340 Point San Bruno Boulevard, South San Francisco, CA, 94080, USA., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Wellcome Trust Sanger Institute, Hinxton, UK., Giedraitis V; Department of Public Health and Caring Sciences, Uppsala Universitet, Uppsala, Sweden., Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Silbernagel G; Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Meyer J; Institute of Genetic Epidemiology,Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Müller-Nurasyid M; Institute of Genetic Epidemiology,Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology and Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI, University Medical Center, Johannes Gutenberg University, 55101, Mainz, Germany., Ganna A; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sarin AP; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Public Health Genomics Unit, Finnish Institute for Health and Welfare, Helsinki, Finland., Yengo L; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Shungin D; Department of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden.; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.; Department of Odontology, Umeå University, Umeå, Sweden., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Horikoshi M; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; RIKEN, Center for Integrative Medical Sciences, Laboratory for Endocrinology, Metabolism and Kidney Disease, Yokohama, Japan., An P; Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA., Sanna S; Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, Italy.; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Boettcher Y; Department of Medicine, University of Leipzig, Leipzig, Germany.; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Rayner NW; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Wellcome Trust Sanger Institute, Hinxton, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Zemunik T; Faculty of Medicine, University of Split, Split, Croatia., Iperen EV; Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Kovacs P; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Hastie ND; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Wild SH; Usher Institute, University of Edinburgh, Edinburgh, UK., McLachlan S; Usher Institute, University of Edinburgh, Edinburgh, UK., Campbell S; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Polasek O; Faculty of Medicine, University of Split, Split, Croatia., Carlson O; Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, MD, USA., Egan J; Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, MD, USA., Kiess W; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.; Pediatric Research Center, Department of Women's & Child Health, University of Leipzig, Leipzig, Germany., Willemsen G; Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands., Kuusisto J; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Laakso M; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Dimitriou M; Department of Dietetics-Nutrition, Harokopio University, Athens, Greece., Hicks AA; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of LübeckLübeckGermany), Bolzano, Italy., Rauramaa R; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Bandinelli S; Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy., Thorand B; German Center for Diabetes Research (DZD, München-Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Liu Y; Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Miljkovic I; Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, PA, USA., Lind L; Department of Medical Sciences, Uppsala University, Akademiska sjukhuset, Uppsala, Sweden., Doney A; Pat McPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Perola M; Public Health Genomics Unit, Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland.; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Estonian Genome Center, University of Tartu, Tartu, Estonia., Hingorani A; Department of Epidemiology and Public Health, University College London, London, UK., Kivimaki M; Department of Epidemiology and Public Health, University College London, London, UK., Kumari M; Department of Epidemiology and Public Health, University College London, London, UK.; University of Essex, Wivenhoe Park, Colchester, Essex, UK., Bennett AJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Groves CJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Herder C; German Center for Diabetes Research (DZD, München-Neuherberg, Germany.; Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Koistinen HA; Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland.; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, P.O. Box 340, Haartmaninkatu 4, Helsinki, FI-00029, Finland.; Minerva Foundation Institute for Medical Research, Biomedicum 2U, Tukholmankatu 8, Helsinki, FI-00290, Finland., Kinnunen L; Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Faire U; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Bakker SJL; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Uusitupa M; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Palmer CNA; Pat McPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Jukema JW; Dept of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Netherlands Heart Institute, Utrecht, the Netherlands., Sattar N; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom., Pouta A; Department of Government Services, Finnish Institute for Health and Welfare, Helsinki, Finland.; PEDEGO Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Boerwinkle E; IMM Center for Human Genetics, University of Texas Health Science Center at Houston, Houston, TX, USA.; Division of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Pankow JS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MiI, USA., Magnusson PK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Krus U; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden., Scapoli C; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., de Geus EJCN; Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, VU University medical center, Amsterdam, the Netherlands., Blüher M; Department of Medicine, University of Leipzig, Leipzig, Germany.; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA., Wolffenbuttel BHR; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Province MA; Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA., Abecasis GR; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Meigs JB; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; General Medicine Division, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hovingh GK; Department of Vascular Medicine, Amsterdam UMC, Amsterdam, the Netherlands.; Novo Nordisk A/S, Copenhagen, Denmark., Lindström J; Finnish Institute for Health and Welfare, Diabetes Prevention Unit, Helsinki, Finland., Wilson JF; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Usher Institute, University of Edinburgh, Edinburgh, UK., Wright AF; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Dedoussis GV; Department of Dietetics-Nutrition, Harokopio University, Athens, Greece., Bornstein SR; Department of Medicine, Division for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Schwarz PEH; Department for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany., Tönjes A; Department of Medicine, University of Leipzig, Leipzig, Germany.; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Winkelmann BR; Cardiology Group, Frankfurt-Sachsenhausen, Germany., Boehm BO; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore and Imperial College London, Singapore, Singapore., März W; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany., Metspalu A; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Price JF; Usher Institute, University of Edinburgh, Edinburgh, UK., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Wellcome Trust Sanger Institute, Hinxton, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD, King Abdulaziz University, Jeddah, Saudi Arabia., Körner A; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.; Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA., Lakka TA; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland., Keinanen-Kiukaanniemi SM; Faculty of Medicine, Center for Life Course Health Research, University of Oulu, Oulu, Finland.; Unit of General Practice, Oulu University Hospital, Oulu, Finland., Saaristo TE; Finnish Diabetes Association, Tampere, Finland.; Pirkanmaa Hospital District, Tampere, Finland., Bergman RN; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Tuomilehto J; Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Centre for Vascular Prevention, Danube-University Krems, Krems, Austria.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Männistö S; Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.; Department of Public Health & Clinical Medicine, Units of Medicine and Nutritional Research, Umeå University, Umeå, Sweden., Hayward C; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Vitart V; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Kaprio J; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland., Visvikis-Siest S; Université de Lorraine, IGE-PCV, F-54000, Nancy, France., Balkau B; Inserm, CESP Center for Research in Epidemiology and Public Health, U1018, Villejuif, France.; Univ Paris-Saclay, Univ Paris Sud, UVSQ, UMRS 1018, UMRS 1018, Villejuif, France., Altshuler D; Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Rudan I; Usher Institute, University of Edinburgh, Edinburgh, UK., Stumvoll M; Department of Medicine, University of Leipzig, Leipzig, Germany.; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Campbell H; Usher Institute, University of Edinburgh, Edinburgh, UK., van Duijn CM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Centre for Medical Systems Biology, Leiden, the Netherlands., Gieger C; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD, München-Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Illig T; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.; Institute of Human Genetics, Hannover Medical School, Hannover, Germany., Ferrucci L; Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Pramstaller PP; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of LübeckLübeckGermany), Bolzano, Italy.; Department of Neurology, General Central Hospital, Bolzano, Italy.; Department of Neurology, University of Lübeck, Lübeck, Germany., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Frayling TM; Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, UK., Shuldiner AR; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA.; The Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Palmer LJ; School of Public Health, University of Adelaide, Adelaide, Australia., Penninx BW; Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands., Meneton P; U872 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, 75006, Paris, France., Harris TB; Geriatric Epidemiology Section, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA., Navis G; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Harst PV; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Smith GD; MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK., Forouhi NG; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Loos RJF; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Salomaa V; Finnish Institute for Health and Welfare, Helsinki, Finland., Soranzo N; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Boomsma DI; Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands., Groop L; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden., Tuomi T; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden.; Endocrinology, Abdominal Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, University of Helsinki and Folkhälsan Research Center, Helsinki, Finland., Hofman A; Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands.; Netherlands Consortium for healthy ageing, the Hague, the Netherlands.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA., Munroe PB; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine University of Iceland, Reykjavik, Iceland., Siscovick DS; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Watkins H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Lecoeur C; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France., Vollenweider P; Department of Medicine, University Hospital Lausanne, Lausanne, Switzerland., Franco-Cereceda A; Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Eriksson P; Cardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Karolinska University Hospital, Solna, Sweden., Jarvelin MR; Department of Epidemiology and Biostatistics and HPA-MRC Center, School of Public Health, Imperial College London, London, UK.; Institue of Health Sciences, University of Oulu, Oulu, Finland., Stefansson K; deCODE Genetics, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland., Hamsten A; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.; Department of Cardiology, Karolinska University Hospital Solna, Stockholm, Sweden., Nicholson G; Department of Statistics, University of Oxford, Oxford, UK., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, UK., Dermitzakis ET; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland., Lindgren CM; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, UK.; Genentech, 340 Point San Bruno Boulevard, South San Francisco, CA, 94080, USA., Froguel P; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; Department of Medicine, Imperial College London, London, UK., Kaakinen MA; Department of Medicine, Imperial College London, London, UK.; School of Biosciences and Medicine, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK., Lyssenko V; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden.; Department of Clinical Science, University of Bergen, Bergen, Norway., Watanabe RM; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA.; Department of Physiology & Neuroscience, Keck School of Medicine of USC, Los Angeles, CA, USA.; USC Diabetes and Obesity Research Institute, Los Angeles, CA, USA., Ingelsson E; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, 94305, USA., Florez JC; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Barroso I; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK.; Exeter Centre of ExcEllence in Diabetes (ExCEED), University of Exeter Medical School, Exeter, UK., Morris AP; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK., Prokopenko I; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom. i.prokopenko@surrey.ac.uk.; Department of Medicine, Imperial College London, London, UK. i.prokopenko@surrey.ac.uk.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. i.prokopenko@surrey.ac.uk.; School of Biosciences and Medicine, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK. i.prokopenko@surrey.ac.uk.; Institute of Biochemistry and Genetics, Ufa Federal Research Centre Russian Academy of Sciences, Ufa, Russian Federation. i.prokopenko@surrey.ac.uk. |
| Corporate Authors: | Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) |
| Source: | Nature communications [Nat Commun] 2021 Jan 05; Vol. 12 (1), pp. 24. Date of Electronic Publication: 2021 Jan 05. |
| Publication Type: | Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-020-19366-9 |
